{"id":10078,"date":"2026-09-17T09:21:19","date_gmt":"2026-09-17T08:21:19","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=10078"},"modified":"2026-09-17T09:21:19","modified_gmt":"2026-09-17T08:21:19","slug":"beyond-virilisation-two-non-functional-ovarian-steroid-cell-tumours-and-a-critical-review-of-the-literature-2026","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/17\/beyond-virilisation-two-non-functional-ovarian-steroid-cell-tumours-and-a-critical-review-of-the-literature-2026\/","title":{"rendered":"Beyond virilisation: Two non-functional ovarian steroid cell tumours and a critical review of the literature (2026)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Type of publication:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Conference abstract<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Author(s):<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">*Huda N.-U.; *Chai A.C.; *Sahu B.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Citation:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BJOG: An International Journal of Obstetrics and Gynaecology. Conference: BGCS 2026 Book of Abstracts. Bristol United Kingdom. 133(Supplement 2) (pp S40-S41), 2026. Date of Publication: 01 Jun 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Background: Ovarian steroid cell tumours (SCTs) are rare sex cord-stromal neoplasms (&lt;0.1% of ovarian tumours). Most secrete androgens causing virilisation, but up to 40% are nonfunctional and discovered incidentally. Their variable presentation and overlapping histology make diagnosis challenging. Objective(s): To describe two cases of non-virilising ovarian SCTs managed at our institution, review their management, and contextualise findings within the current literature. Method(s): We report two patients diagnosed with nonfunctional ovarian SCTs. Case 1: a 77-year-old woman with an incidental left ovarian mass; Case 2: a 56-year-old woman presenting with postmenopausal bleeding and right ovarian mass. Both underwent surgical excision. Histopathology and immunohistochemistry (inhibin, calretinin, Melan-A) confirmed diagnosis. Patients were followed with imaging, tumour markers, and hormonal assays. A literature review of major series and molecular insights was conducted.<br>Result(s): Case 1 had a large (16 x 10 cm) left-sided tumour, FIGO stage IA, with no malignant features. Case 2 had a smaller (5.5 x 4 cm) right-sided tumour, FIGO stage IC2, with capsular invasion. Both patients had uneventful recoveries and remain recurrence-free on long-term surveillance. Literature review highlights the heterogeneity of SCTs, with non-functional tumours comprising ~40% of cases, generally presenting at early stages, and showing favourable outcomes with surgery alone. Histologic predictors of malignancy include tumour size >= 7 cm, mitotic activity, necrosis, and atypia. Molecular data suggest potential links with VHL, FH, and APC mutations, but prognostic markers remain limited. Conclusion(s): Non-functional ovarian SCTs may present incidentally and are often cured with surgery. Accurate diagnosis relies on histology and immunohistochemistry, and lifelong follow-up is recommended due to unpredictable malignant potential.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>DOI:\u00a0<\/strong>10.1111\/1471-0528.70281<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Conference abstract Author(s): *Huda N.-U.; *Chai A.C.; *Sahu B. Citation: BJOG: An International Journal of Obstetrics and Gynaecology. Conference: BGCS 2026 Book of Abstracts. Bristol United Kingdom. 133(Supplement 2) (pp S40-S41), 2026. Date of Publication: 01 Jun<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/17\/beyond-virilisation-two-non-functional-ovarian-steroid-cell-tumours-and-a-critical-review-of-the-literature-2026\/\">Read more <span class=\"screen-reader-text\">Beyond virilisation: Two non-functional ovarian steroid cell tumours and a critical review of the literature (2026)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[200],"tags":[1106,986],"class_list":["post-10078","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-1106","tag-obstetrics-and-gynaecology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=10078"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10078\/revisions"}],"predecessor-version":[{"id":10079,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10078\/revisions\/10079"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=10078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=10078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=10078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}