{"id":10080,"date":"2026-09-17T09:23:14","date_gmt":"2026-09-17T08:23:14","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=10080"},"modified":"2026-09-17T09:23:15","modified_gmt":"2026-09-17T08:23:15","slug":"placental-site-trophoblastic-tumour-beyond-the-reproductive-years-a-rare-cause-of-postmenopausal-bleeding-2026","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/17\/placental-site-trophoblastic-tumour-beyond-the-reproductive-years-a-rare-cause-of-postmenopausal-bleeding-2026\/","title":{"rendered":"Placental site trophoblastic tumour beyond the reproductive years: A rare cause of postmenopausal bleeding (2026)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Type of publication:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Conference abstract<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Author(s):<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">*Kabra S.; *Alayande G.; *Malik N.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Citation:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BJOG: An International Journal of Obstetrics and Gynaecology. Conference: BGCS 2026 Book of Abstracts. Bristol United Kingdom. 133(Supplement 2) (pp S44-S45), 2026. Date of Publication: 01 Jun 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Background: Placental site trophoblastic tumour (PSTT) is a rare subtype of gestational trophoblastic neoplasia arising from intermediate trophoblastic cells at the placental implantation site. It typically occurs in women of reproductive age following a prior pregnancy, although rare cases have been reported in perimenopausal and menopausal women. A UK population-based study reported only 75 cases over a 21-year period. Objective(s): To report a rare presentation of PSTT in a menopausal woman. Method(s): Case report and literature review. Result(s): A 46-year-old woman presented with heavy vaginal bleeding after two years of amenorrhoea. Her last pregnancy was a term caesarean section three years previously. Transvaginal ultrasound showed a postmenopausal endometrial thickness of 6 mm, and she was referred through the urgent suspected cancer pathway. Diagnostic hysteroscopy was attempted but abandoned due to poor visualisation from active bleeding. Pipelle endometrial biopsy revealed an infiltrative lesion composed of intermediate trophoblastic cells with immunohistochemistry positive for AE1\/AE3 and human placental lactogen (hPL), consistent with PSTT. MRI pelvis demonstrated a 3 cm lesion involving the anterior myometrium extending into the endometrial cavity. Staging CT of the chest, abdomen and pelvis showed no distant metastasis. Following multidisciplinary discussion with the regional gestational trophoblastic disease centre, hysterectomy was recommended as definitive treatment. Conclusion(s): PSTT is a rare but important differential diagnosis for postmenopausal bleeding. Early histopathological diagnosis, appropriate imaging and multidisciplinary management are essential for optimal outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>DOI:&nbsp;<\/strong>10.1111\/1471-0528.70281<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Conference abstract Author(s): *Kabra S.; *Alayande G.; *Malik N. Citation: BJOG: An International Journal of Obstetrics and Gynaecology. Conference: BGCS 2026 Book of Abstracts. Bristol United Kingdom. 133(Supplement 2) (pp S44-S45), 2026. Date of Publication: 01 Jun<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/17\/placental-site-trophoblastic-tumour-beyond-the-reproductive-years-a-rare-cause-of-postmenopausal-bleeding-2026\/\">Read more <span class=\"screen-reader-text\">Placental site trophoblastic tumour beyond the reproductive years: A rare cause of postmenopausal bleeding (2026)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[200],"tags":[1106,986],"class_list":["post-10080","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-1106","tag-obstetrics-and-gynaecology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=10080"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10080\/revisions"}],"predecessor-version":[{"id":10081,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10080\/revisions\/10081"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=10080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=10080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=10080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}