{"id":10146,"date":"2026-09-28T13:43:02","date_gmt":"2026-09-28T12:43:02","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=10146"},"modified":"2026-09-28T13:43:03","modified_gmt":"2026-09-28T12:43:03","slug":"a-multicentered-retrospective-cohort-study-comparing-jak-inhibitor-therapies-in-moderate-to-severe-ulcerative-colitis-2026","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/28\/a-multicentered-retrospective-cohort-study-comparing-jak-inhibitor-therapies-in-moderate-to-severe-ulcerative-colitis-2026\/","title":{"rendered":"A multicentered retrospective cohort study comparing JAK inhibitor therapies in moderate-to-severe ulcerative colitis (2026)"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Type of publication:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Journal article<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Author(s):<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kumar, Aditi; Baxter, Joshua; Rimmer, Peter; Noble, Ben; Bower, Joshua; Makki, Mujeeb Ullah; Hatta, Ayiesha; Chikhlia, Anmol; Cheesbrough, Jonathan; Disney, Ben; *Muir, Josh; *Karova, Mariya; *Butterworth, Jeffrey; Sagar, Nidhi; Al-Talib, Ismaeel; Nahal, Jasbir; Ali, Nasima; Sagar, Vandana; Varyani, Fumi; Smith, Sam; Bourne, Stephanie; Hsu, Yu-Kai; Eltahir, Almoiez; de Silva, Shanika; Harvey, Philip.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Citation:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Crohn's &amp; Colitis 360. 8(2):otag045, 2026 Apr.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Background: Tofacitinib, filgotinib, and upadacitinib are Janus kinase inhibitors (JAKi) that have demonstrated efficacy in ulcerative colitis (UC) against placebo. This study aims to compare the clinical efficacy between these drugs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Methods: This is a multicentered, retrospective cohort study. Patients with UC starting a JAKi were recruited between 2018 and 2024 when starting their first JAKi. Clinical remission and response, based on clinical scores, calprotectin, and endoscopic measurement, were assessed at 3 and 6 months. Both independent and combined variable outcomes were analyzed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Results: Two hundred and seventy patients were included in the analysis, of which 70 (26%) were on upadacitinib, 51 (19%) on filgotinib, and 149 (55%) on tofacitinib. Clinical, biochemical, and endoscopic remission at 6 months was 91%, 71%, and 80% for upadacitinib; 78%, 67%, and 50% for filgotinib; 73%, 51%, and 44% for tofacitinib. Upadacitinib demonstrated significantly greater clinical response (P = .027) and remission (P = .037) rates at 6 months than tofacitinib. Drug persistence at 12 months was 86% for upadacitinib, 72% for filgotinib, and 69% for tofacitinib. Upadacitinib demonstrated significantly greater 6-month remission rates compared to tofacitinib in the bio-exposed cohort (71% vs 52%, P = .022) and in the bio-naive cohort (93% vs 50%, P = .009). The incidence rates for hospital admissions were 10.2, 21.9, and 14.1 and for colectomies were 6.7, 10.0, and 5.0 per 1000 patient-months at risk for upadacitinib, filgotinib and tofacitinib, respectively.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Conclusion: This study demonstrates that upadacitinib is more likely to achieve 6-month response and remission compared to tofacitinib. In both bio-naive and bio-exposed patients, upadacitinib was more likely to achieve remission at 6 months. The efficacy of JAKi does not appear diminished by prior biologic use.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>DOI:<\/strong> 10.1093\/crocol\/otag045<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/libkey.io\/libraries\/1791\/articles\/710956595\/full-text-file?utm_source=nomad\">Link to full-text<\/a> [open access]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): Kumar, Aditi; Baxter, Joshua; Rimmer, Peter; Noble, Ben; Bower, Joshua; Makki, Mujeeb Ullah; Hatta, Ayiesha; Chikhlia, Anmol; Cheesbrough, Jonathan; Disney, Ben; *Muir, Josh; *Karova, Mariya; *Butterworth, Jeffrey; Sagar, Nidhi; Al-Talib, Ismaeel; Nahal, Jasbir; Ali,<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2026\/09\/28\/a-multicentered-retrospective-cohort-study-comparing-jak-inhibitor-therapies-in-moderate-to-severe-ulcerative-colitis-2026\/\">Read more <span class=\"screen-reader-text\">A multicentered retrospective cohort study comparing JAK inhibitor therapies in moderate-to-severe ulcerative colitis (2026)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1001,200],"tags":[1106,221,1002],"class_list":["post-10146","post","type-post","status-publish","format-standard","hentry","category-open-access","category-staff-publication","tag-1106","tag-gastroenterology","tag-gold-open-access"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=10146"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10146\/revisions"}],"predecessor-version":[{"id":10147,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/10146\/revisions\/10147"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=10146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=10146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=10146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}