{"id":1881,"date":"2015-09-07T11:00:51","date_gmt":"2015-09-07T11:00:51","guid":{"rendered":"http:\/\/library.sath.nhs.uk\/intelligence\/?p=1881"},"modified":"2021-03-01T15:19:42","modified_gmt":"2021-03-01T15:19:42","slug":"high-grade-vaginal-intraepithelial-neoplasia-vain23-comparison-of-clinical-outcomes-between-treated-and-untreated-patients-in-an-observational-cohort-study-2015","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2015\/09\/07\/high-grade-vaginal-intraepithelial-neoplasia-vain23-comparison-of-clinical-outcomes-between-treated-and-untreated-patients-in-an-observational-cohort-study-2015\/","title":{"rendered":"High-grade vaginal intraepithelial neoplasia (VAIN2\/3): comparison of clinical outcomes between treated and untreated patients in an observational cohort study (2015)"},"content":{"rendered":"

Type of publication:<\/strong>
\nConference abstract<\/p>\n

Author(s):<\/strong>
\n*Pandey B., *Papoutsis D., *Guttikonda S., *Ritchie J., *Reed N., *Panikkar J., *Blundell S.<\/p>\n

Citation:<\/strong>
\nBJOG: An International Journal of Obstetrics and Gynaecology, April 2015, vol.\/is. 122\/(149)<\/p>\n

Abstract:<\/strong>
\nIntroduction We aimed to compare the clinical outcomes between treated and untreated patients with high-grade vaginal intraepithelial neoplasia (VAIN2\/3) in our colposcopy unit. Methods The clinical records of all patients diagnosed with VAIN and vaginal cancer over the time period of 1981-2012 were retrieved and reviewed. The primary outcome was to identify the progression of treated versus untreated patients with VAIN2\/3 to vaginal cancer and to compare persistent VAIN disease in both subgroups. The secondary outcome was to identify any associations between particular demographic features of treated\/ untreated VAIN2\/3 patients with their clinical outcome. Results During the time period of this observational cohort study 36 patients of which 11 patients with VAIN1, 19 with VAIN2\/3 disease and 6 with vaginal cancer were identified. In those with VAIN2\/3 (n = 19) the diagnosis was made in a younger age in the subgroup of treated patients (n = 8) versus the untreated patients (n = 11) (47 +\/- 7.1 versus 54.3 +\/- 11.5 years old). Nulliparity and smoking status were similar between the two cohorts. The median follow-up for the untreated women was 7 years (range 1-22 years). In the treated VAIN2\/3 group, median time from diagnosis to treatment was 4 years (range 0.2-7 years), and median follow-up after treatment was 7 years (range 0.5-18 years). Treatment methods were ablation (n = 4), excision of lesion (n = 2) and vaginectomy (n = 2). There were no cases of treated VAIN2\/3 patients (0%) that progressed to vaginal cancer, whereas n = 3 cases of untreated VAIN2\/3 patients (21.4%) progressed to vaginal cancer. Following initial VAIN2\/3 diagnosis, 8\/11 cases of untreated VAIN2\/3 (72.7%) had persistent disease as identified in follow-up cytology\/colposcopy\/vaginal biopsies. In the treated VAIN2\/3 patients, 5\/5 cases (100%) had persistent disease post-diagnosis but after treatment this decreased to 2\/7 cases (28.5%). Conclusion Treated VAIN2\/3 patients were of younger age but of similar smoking status and parity in comparison to untreated patients. Three cases of untreated VAIN2\/3 progressed to vaginal cancer, whereas there were no such cases of patients receiving treatment for VAIN2\/3. The VAIN2\/3 patients who received treatment had a higher rate of persistent VAIN disease at followup post-diagnosis (100% versus 72.7%), but after treatment this rate fell down to 28.5%. Further studies are needed to conclude whether treatment of VAIN2\/3 disease reduces the rate of VAIN disease persistence and affects the progression to vaginal cancer.<\/p>\n

Link to full-text: http:\/\/ovidsp.ovid.com\/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00134415-201504001-00343&LSLINK=80&D=ovft<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Type of publication: Conference abstract Author(s): *Pandey B., *Papoutsis D., *Guttikonda S., *Ritchie J., *Reed N., *Panikkar J., *Blundell S. Citation: BJOG: An International Journal of Obstetrics and Gynaecology, April 2015, vol.\/is. 122\/(149) Abstract: Introduction We aimed to compare the…<\/span><\/p>\n

Read more High-grade vaginal intraepithelial neoplasia (VAIN2\/3): comparison of clinical outcomes between treated and untreated patients in an observational cohort study (2015)<\/span> ›<\/span><\/a><\/div>\n

<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[569,345,986],"class_list":["post-1881","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-569","tag-gynaecological-neoplasms","tag-obstetrics-and-gynaecology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/1881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=1881"}],"version-history":[{"count":2,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/1881\/revisions"}],"predecessor-version":[{"id":3037,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/1881\/revisions\/3037"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=1881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=1881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=1881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}