{"id":4439,"date":"2017-06-28T10:37:05","date_gmt":"2017-06-28T10:37:05","guid":{"rendered":"http:\/\/www.library.sath.nhs.uk\/research\/?p=4439"},"modified":"2021-03-01T15:21:35","modified_gmt":"2021-03-01T15:21:35","slug":"does-cin2-have-the-same-aggressive-potential-as-cin3-a-secondary-analysis-of-high-grade-cytology-recurrence-in-women-treated-with-cold-coagulation-cervical-treatment-2017-2","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2017\/06\/28\/does-cin2-have-the-same-aggressive-potential-as-cin3-a-secondary-analysis-of-high-grade-cytology-recurrence-in-women-treated-with-cold-coagulation-cervical-treatment-2017-2\/","title":{"rendered":"Does CIN2 Have the Same Aggressive Potential As CIN3? A Secondary Analysis of High-Grade Cytology Recurrence in Women Treated with Cold-Coagulation Cervical Treatment (2017)"},"content":{"rendered":"<p><strong>Type of publication:<\/strong><br \/>\nJournal article<\/p>\n<p><strong>Author(s):<\/strong><br \/>\n*Papoutsis D.; *<a href=\"https:\/\/orcid.org\/0000-0001-6891-7390\" target=\"_blank\" rel=\"noopener noreferrer\">Underwood M<\/a> <a href=\"https:\/\/orcid.org\/0000-0001-6891-7390\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-5757 size-full\" src=\"http:\/\/www.library.sath.nhs.uk\/wp-content\/uploads\/2020\/05\/orcid_16x16.gif\" alt=\"\" width=\"16\" height=\"16\" \/><\/a>.; *Parry-Smith W.; *Panikkar J.<\/p>\n<p><strong>Citation:<\/strong><br \/>\nGeburtshilfe und Frauenheilkunde; Mar 2017; vol. 77 (no. 3); p. 284-289<\/p>\n<p><strong>Abstract:<\/strong><br \/>\nIntroduction To determine whether women with CIN2 versus CIN3 on pretreatment cervical punch biopsy have less high-grade cytology recurrence following cold-coagulation cervical treatment. Materials and Methods This was a retrospective study of women having had cold coagulation between 2001-2011 in our colposcopy unit. Women with previous cervical treatment were excluded. Results We identified 402 women with 260 (64.7?%) cases of CIN2 and 142 (35.3?%) cases of CIN3 on pretreatment cervical punch biopsy. In the total sample, the mean age of women was 27.5 years (SD = 4.9), 75.1?% were nulliparous and 36.6?% were smokers. Referral cytology and pretreatment colposcopic appearance were high-grade in 62.7?% and 57.1?%. The mean follow-up period was 2.8 years (SD = 2.1). Women with CIN2 on pretreatment cervical biopsy when compared to those\u00a0with CIN3 had less frequently high-grade referral cytology and high-grade pretreatment colposcopic appearances, and had less pretreatment cervical biopsies taken. During the follow-up period, women with CIN2 on pretreatment cervical biopsy had less high-grade cytology recurrence when compared to those women with CIN3 (1.9 vs. 5.6?%, p = 0.046). Multiple stepwise Cox regression analysis showed that women with CIN3 on pretreatment cervical biopsy had 3.21 times greater hazard for high-grade cytology recurrence (HR = 3.21, 95?% CI: 1.05-9.89; p = 0.041) in comparison with CIN2 cases. Conclusion We found that women with CIN2 on\u00a0pretreatment cervical punch biopsy had less high-grade cytology recurrence following cold-coagulation treatment in comparison to those with CIN3. This finding lends support to the theory that CIN2 even though a\u00a0high-grade abnormality might not have the same aggressive potential as CIN3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *Papoutsis D.; *Underwood M .; *Parry-Smith W.; *Panikkar J. Citation: Geburtshilfe und Frauenheilkunde; Mar 2017; vol. 77 (no. 3); p. 284-289 Abstract: Introduction To determine whether women with CIN2 versus CIN3 on pretreatment cervical<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2017\/06\/28\/does-cin2-have-the-same-aggressive-potential-as-cin3-a-secondary-analysis-of-high-grade-cytology-recurrence-in-women-treated-with-cold-coagulation-cervical-treatment-2017-2\/\">Read more <span class=\"screen-reader-text\">Does CIN2 Have the Same Aggressive Potential As CIN3? A Secondary Analysis of High-Grade Cytology Recurrence in Women Treated with Cold-Coagulation Cervical Treatment (2017)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[677,553,986],"class_list":["post-4439","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-677","tag-cytology","tag-obstetrics-and-gynaecology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/4439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=4439"}],"version-history":[{"count":3,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/4439\/revisions"}],"predecessor-version":[{"id":6007,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/4439\/revisions\/6007"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=4439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=4439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=4439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}