{"id":4661,"date":"2017-11-28T10:03:22","date_gmt":"2017-11-28T10:03:22","guid":{"rendered":"http:\/\/www.library.sath.nhs.uk\/research\/?p=4661"},"modified":"2018-03-05T16:10:45","modified_gmt":"2018-03-05T16:10:45","slug":"partial-breast-radiotherapy-after-breast-conservation-surgery-for-patients-with-early-breast-cancer-uk-import-low-trial-5-year-results-from-a-multicentre-randomised-controlled-phase-3-non-infer-2","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2017\/11\/28\/partial-breast-radiotherapy-after-breast-conservation-surgery-for-patients-with-early-breast-cancer-uk-import-low-trial-5-year-results-from-a-multicentre-randomised-controlled-phase-3-non-infer-2\/","title":{"rendered":"Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK\/06\/003) phase III trial (2017)"},"content":{"rendered":"

Type of publication:<\/strong>
\nConference abstract<\/p>\n

Author(s):<\/strong>
\nColes C.; Griffin C.; Bhattacharya I.; Emson M.; Haviland J.; Hopwood P.; Kaggwa R.; Bliss J.; Kirby A.; Donovan\u00a0E.; *Agrawal R.; Alhasso A.; Brunt A.M.; Ciurlionis L.; Chan H.; Harnett A.; Sawyer E.; Sybdikus I.; Tsang Y.;\u00a0Wheatley D.; Wilcox M.; Yarnold J.; Jefford M.<\/p>\n

Citation:<\/strong>
\nRadiotherapy and Oncology; May 2017; vol. 123<\/p>\n

Abstract:<\/strong>
\nBackground: Local cancer relapse rates after breast conservation surgery followed by radiotherapy have fallen\u00a0sharply in many countries with risk influenced by patient age and clinico-pathological factors. In women at\u00a0lower than average risk of local relapse, partial breast radiotherapy restricted to the vicinity of the original\u00a0tumour is hypothesised to improve the balance of beneficial versus adverse effects compared with whole breast\u00a0radiotherapy. Methods: The IMPORT LOW trial (ISRCTN12852634) recruited women aged >=50 years after\u00a0breast conserving surgery for invasive ductal adenocarcinoma pT<=3cm, pN0- 3, G1-3 and >=2mm resection\u00a0margins. Using 15 daily treatments, patients were randomly allocated (1:1:1) to 40 Gy whole breast\u00a0radiotherapy (control), 36 Gy whole breast plus 40 Gy to partial breast (reduced dose) or 40 Gy partial breast\u00a0only (partial breast). Primary endpoint was ipsilateral local relapse rate (80% power to exclude a +2.5% noninferiority\u00a0margin at 5 years for each test group). Findings: Between May 2007 and October 2010, 2018 women\u00a0were recruited (control n=675, reduced dose: n=674, partial breast: n=669). With a 72.2 month median followup\u00a0(IQR 61.7-83.2), 5-year local relapse rates were 1.1% (95%CI 0.5-2.3), 0.2% (0.02-1.2) and 0.5% (0.2-1.4) in\u00a0control, reduced dose and partial breast groups. Absolute differences in local relapse rate compared with the\u00a0control group were -0.73% (-0.99, 0.22) for the reduced dose and -0.38% (-0.84, 0.90) for the partial breast\u00a0groups, demonstrating non-inferiority for both test groups. Photographs, patients and clinicians reported\u00a0similar or lower levels of adverse effects after reduced dose or partial breast radiotherapy compared with\u00a0whole breast radiotherapy (see Table 1). (Table presented) Interpretation: At 5 years, partial breast and reduced
\ndose radiotherapy showed local relapse rates non-inferior to that observed following whole breast\u00a0radiotherapy and produced equivalent or milder late normal tissue side effects. This simple radiotherapy\u00a0technique is implementable in radiotherapy centres worldwide.<\/p>\n","protected":false},"excerpt":{"rendered":"

Type of publication: Conference abstract Author(s): Coles C.; Griffin C.; Bhattacharya I.; Emson M.; Haviland J.; Hopwood P.; Kaggwa R.; Bliss J.; Kirby A.; Donovan\u00a0E.; *Agrawal R.; Alhasso A.; Brunt A.M.; Ciurlionis L.; Chan H.; Harnett A.; Sawyer E.; Sybdikus…<\/span><\/p>\n

Read more Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK\/06\/003) phase III trial (2017)<\/span> ›<\/span><\/a><\/div>\n

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