{"id":6079,"date":"2020-07-02T16:58:36","date_gmt":"2020-07-02T15:58:36","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=6079"},"modified":"2022-09-01T12:31:22","modified_gmt":"2022-09-01T11:31:22","slug":"role-of-flavonoids-in-the-management-of-acutely-symptomatic-haemorrhoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-2019","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2020\/07\/02\/role-of-flavonoids-in-the-management-of-acutely-symptomatic-haemorrhoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-2019\/","title":{"rendered":"Role of flavonoids in the management of acutely symptomatic haemorrhoids: A systematic review and meta-analysis of randomized, controlled trials (2019)"},"content":{"rendered":"<p><strong>Type of publication:<\/strong><br \/>\nConference abstract<\/p>\n<p><strong>Author(s):<\/strong><br \/>\n*Rehman S.; Miles W.; Sains P.; Sajid M.<\/p>\n<p><strong>Citation:<\/strong><br \/>\nBritish Journal of Surgery; Sep 2019; vol. 106, S5, p. 110<\/p>\n<p><strong>Abstract:<\/strong><br \/>\nAims: The objective of this article is to assess the role of role of flavonoids in the management of acutely<br \/>\nsymptomatic haemorrhoids.<br \/>\nMethod(s): The data retrieved from the published randomized, controlled trials (RCT) regarding the role of flavonoids in the management of acutely symptomatic haemorrhoids was analysed using the principles of metaanalysis. The summated outcome of dichotomous variables was expressed in odds ratio (OR).<br \/>\nResult(s): Ten RCTs on 1478 patients comparing the surgical outcomes in patients having clinically and endoscopically diagnosed acute symptomatic haemorrhoids after using flavonoids versus placebo preparation were analysed. In the random effects model analysis using the statistical software Review Manager 5.3, the symptomatic relief (OR, 0.48; 95% CI, 0.16, 1.3928; z = 1.36; P = 0.18), satisfaction on pain relief (OR, 0.30; 95% CI, 0.08, 1.07; z = 1.86; P = 0.06), recurrence (OR, 0.48; 95% CI, 0.14, 1.63; z = 1.17; P = 0.24) and complications rate (OR, 1.31; 95% CI, 0.49, 3.54; z = 0.54; P = 0.59) were statistically similar in both groups. However, symptomatic haemorrhoidal bleeding control rate was higher in flavonoids group (OR, 0.33; 95% CI, 0.13, 0.84; z = 2.33; P = 0.02).<br \/>\nConclusion(s): Use of flavonoids to treat symptomatic acute haemorrhoids failed to demonstrate better effectiveness over traditional placebo remedies except better bleeding control.<\/p>\n<p><a href=\"https:\/\/bjssjournals.onlinelibrary.wiley.com\/doi\/10.1002\/bjs.11342\" target=\"_blank\" rel=\"noopener noreferrer\">Link to full-text<\/a> [NHS OpenAthens account required]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Conference abstract Author(s): *Rehman S.; Miles W.; Sains P.; Sajid M. Citation: British Journal of Surgery; Sep 2019; vol. 106, S5, p. 110 Abstract: Aims: The objective of this article is to assess the role of role<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2020\/07\/02\/role-of-flavonoids-in-the-management-of-acutely-symptomatic-haemorrhoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-2019\/\">Read more <span class=\"screen-reader-text\">Role of flavonoids in the management of acutely symptomatic haemorrhoids: A systematic review and meta-analysis of randomized, controlled trials (2019)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[832,953,1024],"class_list":["post-6079","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-832","tag-haemorrhoidal-disease","tag-systematic-review"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=6079"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6079\/revisions"}],"predecessor-version":[{"id":6080,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6079\/revisions\/6080"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=6079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=6079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=6079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}