{"id":6736,"date":"2021-10-07T10:20:30","date_gmt":"2021-10-07T09:20:30","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=6736"},"modified":"2021-10-07T10:20:30","modified_gmt":"2021-10-07T09:20:30","slug":"primary-acinic-cell-carcinoma-in-a-young-female-patient-a-case-report-2021","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2021\/10\/07\/primary-acinic-cell-carcinoma-in-a-young-female-patient-a-case-report-2021\/","title":{"rendered":"Primary acinic cell carcinoma in a young female patient: a case report (2021)"},"content":{"rendered":"<p><strong>Type of publication:<\/strong><br \/>\nJournal article<\/p>\n<p><strong>Author(s):<\/strong><br \/>\n*Venkatasami, M ; *Harrison, K<\/p>\n<p><strong>Citation:<\/strong><br \/>\nOral Surgery, Oral Medicine, Oral Pathology &amp; Oral Radiology; Jul 2021; vol. 132 (no. 1)<\/p>\n<p><strong>Abstract:<\/strong><br \/>\nBackground: Acinic cell carcinoma (ACC) is a rare, low-grade tumor, accounting for about 5% of all primary salivary gland malignancies. ACCs predominate in the parotid gland, are seen in the fifth and sixth decades of life, and have a female predilection. Well-differentiated and low-grade tumors are associated with a favorable prognosis.<br \/>\nDescription: We report a case of a 16-year-old female patient presenting with a right parotid lump that had been slowly increasing over the past year. Clinical examination revealed a 1.5-cm right parotid nodule with no facial nerve involvement and presence of cervical lymphadenopathy. Her past medical history was unremarkable.<br \/>\nFindings: Radiological investigations revealed a well-circumscribed, lobulated lesion in the anterior right parotid gland with presence of reactive lymph nodes bilaterally. Fine-needle aspiration showed granular cells with a differential diagnosis of oncocytoma, Warthin's tumor, or acinic cell carcinoma. Histologic examination showed a multinodular appearance with some marked granular cytoplasm with oncolytic and lymphoid infiltrate. The results of immunohistochemistry were negative for S100 and positive with DOG-1. There were widespread periodic acid-Schiff diastase-resistant granules throughout the tumor cells, with a Ki67 proliferation index of approximately 5%.<br \/>\nOutcome: The tumor was completely excised, and the patient made a full recovery and was considered to have a good long-term prognosis.<br \/>\nConclusions: This is an unusual case of ACC seen in this age group and gender, where less than 4% of cases of ACC have been reported in patients younger than 20. It is important to consider differential diagnoses of salivary gland pathology, such as ACC, in the young female patient.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *Venkatasami, M ; *Harrison, K Citation: Oral Surgery, Oral Medicine, Oral Pathology &amp; Oral Radiology; Jul 2021; vol. 132 (no. 1) Abstract: Background: Acinic cell carcinoma (ACC) is a rare, low-grade tumor, accounting for<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2021\/10\/07\/primary-acinic-cell-carcinoma-in-a-young-female-patient-a-case-report-2021\/\">Read more <span class=\"screen-reader-text\">Primary acinic cell carcinoma in a young female patient: a case report (2021)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[979,759,353],"class_list":["post-6736","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-979","tag-head-and-neck-cancer","tag-oncology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=6736"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6736\/revisions"}],"predecessor-version":[{"id":6737,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/6736\/revisions\/6737"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=6736"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=6736"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=6736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}