{"id":7116,"date":"2022-10-28T11:38:51","date_gmt":"2022-10-28T10:38:51","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=7116"},"modified":"2022-12-08T14:36:24","modified_gmt":"2022-12-08T14:36:24","slug":"quality-of-life-and-two-year-results-of-a-randomized-phase-iii-study-of-dysphagiaoptimized-intensity-modulated-radiotherapy-do-imrt-versus-standard-imrt-simrt-in-head-and-neck-cancer-2022","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2022\/10\/28\/quality-of-life-and-two-year-results-of-a-randomized-phase-iii-study-of-dysphagiaoptimized-intensity-modulated-radiotherapy-do-imrt-versus-standard-imrt-simrt-in-head-and-neck-cancer-2022\/","title":{"rendered":"Quality of life and two-year results of a randomized phase III study of dysphagiaoptimized intensity modulated radiotherapy (DO-IMRT) versus standard IMRT (SIMRT) in head and neck cancer (2022)"},"content":{"rendered":"

Type of publication:<\/strong>
Conference abstract<\/p>\n

Author(s):<\/strong>
Nutting C.; Rooney K.; Foran B.; *Pettit L.; Beasley M.; Finneran L.; Roe J.; Tyler J.; Roques T.; Cook A.; Petkar I.; Bhide S.; Srinivasan D.; Boon C.; De Winton E.; Frogley R.; Sydenham M.A.; Emson M.; Hall E.<\/p>\n

Citation:<\/strong>
Journal of Clinical Oncology. Conference: Annual Meeting of the American Society of Clinical Oncology, ASCO 2022. Online. 40(16 Supplement 1) (no pagination), 2022. Date of Publication: June 2022<\/p>\n

Abstract:<\/strong>
Background: Most newly diagnosed oro- & hypopharngeal cancers (OPC, HPC) are treated with (chemo) RT with curative intent but at the consequence of adverse effects on quality of life. We investigated if using DO-IMRT to reduce RT dose to the dysphagia\/aspiration related structures (DARS) improved swallowing function compared to S-IMRT. Method(s): Patients with T1-4, N0-3, M0 OPC\/HPC were randomised 1:1 to S-IMRT (65 Gray (Gy)\/30 fractions (f) to primary & nodal tumour; 54Gy\/30f to remaining pharyngeal subsite & nodal areas at risk of microscopic disease) or DO-IMRT. The volume of the superior & middle pharyngeal constrictor muscle (PCM) (OPC) or inferior PCM (HPC) lying outside the high-dose target volume was set a mandatory mean dose constraint in DO-IMRT. Treatment allocation was by minimisation balanced by centre, use of induction\/concomitant chemotherapy, tumour site & AJCC stage. Primary endpoint was mean MD Anderson Dysphagia Inventory (MDADI) composite score 12 months after RT. Secondary endpoints included University of Washington (UW)-Qol, Performance Status Scale Head & Neck (PSS-HN) domain scores (range: 0-100), swallow volume, swallow capacity and local control. Result(s): 112 patients (56 S-IMRT, 56 DO-IMRT) were randomised from 22 UK & Ireland centres from 06\/2016 \u2013 04\/2018. 111\/112 had RT doses as prescribed (1 patient died before RT). Outcome measures at 12 and 24 months are summarised below. DO-IMRT had higher MDADI scores at 12 (p = 0.04) and 24 (p = 0.07) months. Clinically important improvements in swallowing function were seen in patients receiving DO-IMRT using PSS-HN domains and the UW-QoL tool. Conclusion(s): DO-IMRT improved patient reported swallowing function compared with S-IMRT. Improvements were seen in overall MDADI as well as functional scores in both PSS-HN and UW-QoL.<\/p>\n

Link to full-text<\/a> [no password required]<\/p>\n","protected":false},"excerpt":{"rendered":"

Type of publication:Conference abstract Author(s):Nutting C.; Rooney K.; Foran B.; *Pettit L.; Beasley M.; Finneran L.; Roe J.; Tyler J.; Roques T.; Cook A.; Petkar I.; Bhide S.; Srinivasan D.; Boon C.; De Winton E.; Frogley R.; Sydenham M.A.; Emson…<\/span><\/p>\n

Read more Quality of life and two-year results of a randomized phase III study of dysphagiaoptimized intensity modulated radiotherapy (DO-IMRT) versus standard IMRT (SIMRT) in head and neck cancer (2022)<\/span> ›<\/span><\/a><\/div>\n

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