{"id":7576,"date":"2023-08-08T09:55:26","date_gmt":"2023-08-08T08:55:26","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=7576"},"modified":"2025-08-26T09:42:13","modified_gmt":"2025-08-26T08:42:13","slug":"management-and-assessment-of-indeterminate-u3-thyroid-nodules-a-5-year-multisite-retrospective-study-2023","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2023\/08\/08\/management-and-assessment-of-indeterminate-u3-thyroid-nodules-a-5-year-multisite-retrospective-study-2023\/","title":{"rendered":"Management And Assessment Of Indeterminate (U3) Thyroid Nodules: A 5-Year Multisite Retrospective Study (2023)"},"content":{"rendered":"<p><strong>Type of publication:<\/strong><br \/>\nJournal article<\/p>\n<p><strong>Author(s):<\/strong><br \/>\n*Patel R.; *Conybeare A.; *Panesar H.; *Badrol S.; *Sood S.<\/p>\n<p><strong>Citation:<\/strong><br \/>\nJournal of Ayub Medical College, Abbottabad : JAMC. 35(2) (pp 216-219), April 2023.<\/p>\n<p><strong>Abstract:<\/strong><br \/>\nBACKGROUND: The U grading of Ultrasound scan (USS) is used to assess the likelihood of malignancy in a thyroid nodule and help determine those that warrant an FNAC confirmation. All those of a U3-5 warrant an FNAC for confirmation and typing. This study aims to review the follow-up practice and the likelihood of picking up a malignancy on subsequent USS and FNAC, for those determined as an indeterminate U3 nodule. METHOD(S): We retrospective reviewed the trust database (Portal) for patients who had a U3 nodule reported on USS identified, and clinical, operative and outcomes data were analysed. RESULT(S): 258 scans were identified over a 5-year period. The average age was 59 (range 15- 95) years old at first USS with a female to the male sex ratio of 4:1. The average number of USS that each patient prior to final diagnosis had averaged at 2.8 (range 1-12). Of those with an initial Thy status, 64 (33%) were benign (Thy2) and a further 49 (25%) were non diagnostics (Thy1). Over time, only 7 nodules were upgraded to a potential malignancy. Of those who underwent surgery, a final histological diagnosis was obtained in 41 cases. Only Thy1, 2 and 3f produced benign final histology results. CONCLUSION(S): For those indeterminate (U3) nodules of Th1-3f, electing for a watch and wait management strategy is reasonable for up to 2.5 years and 4 follow-up scans at an interval of 6-12 months should be implemented. A Thy2 result on a U3 nodule should not be taken as completely reassuring, a high index of suspicion of malignancy must be maintained.<\/p>\n<p><a href=\"https:\/\/jamc.ayubmed.edu.pk\/index.php\/jamc\/article\/view\/11305\/3513\">Link to full-text<\/a> [no password required]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *Patel R.; *Conybeare A.; *Panesar H.; *Badrol S.; *Sood S. Citation: Journal of Ayub Medical College, Abbottabad : JAMC. 35(2) (pp 216-219), April 2023. Abstract: BACKGROUND: The U grading of Ultrasound scan (USS) is<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2023\/08\/08\/management-and-assessment-of-indeterminate-u3-thyroid-nodules-a-5-year-multisite-retrospective-study-2023\/\">Read more <span class=\"screen-reader-text\">Management And Assessment Of Indeterminate (U3) Thyroid Nodules: A 5-Year Multisite Retrospective Study (2023)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[1029,353],"class_list":["post-7576","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-1029","tag-oncology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=7576"}],"version-history":[{"count":2,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7576\/revisions"}],"predecessor-version":[{"id":8894,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7576\/revisions\/8894"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=7576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=7576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=7576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}