{"id":7669,"date":"2023-10-30T09:36:13","date_gmt":"2023-10-30T09:36:13","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=7669"},"modified":"2025-12-02T08:28:33","modified_gmt":"2025-12-02T08:28:33","slug":"the-effects-of-vitamin-d-on-markers-of-glucose-and-obesity-in-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials-2023","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2023\/10\/30\/the-effects-of-vitamin-d-on-markers-of-glucose-and-obesity-in-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials-2023\/","title":{"rendered":"The Effects of Vitamin D on Markers of Glucose and Obesity in Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials (2023)"},"content":{"rendered":"<p><strong>Type of publication:<\/strong><br aria-hidden=\"true\" \/>Systematic Review<\/p>\n<p><strong>Author(s):<\/strong><br aria-hidden=\"true\" \/>Hao, Lei; Lu, Aiyangzi; Gao, Hui; Niu, Jianfei; Prabahar, Kousalya; *Seraj, Shaikh Sanjid; Pan, Yongmei.<\/p>\n<p><strong>Citation:<\/strong><br aria-hidden=\"true\" \/>Clinical Therapeutics. 2023 Sep;45(9):913-920<\/p>\n<p><strong>Abstract:<\/strong><br aria-hidden=\"true\" \/>PURPOSE: The effect of vitamin D effect on glucose markers and obesity in postmenopausal women remains controversial. The current literature contains little information on vitamin D dosage and duration for optimal efficacy in postmenopausal women. This meta-analysis was undertaken to assess the impact of vitamin D on glucose markers and obesity in postmenopausal women. METHODS: A number of databases were used dated up to January 5, 2023, with no language restrictions (PubMed\/MEDLINE, Web of Science, EMBASE, and Scopus). Treatment response from baseline was estimated from the mean within-group analysis, and SDs were used to calculate the treatment response. FINDINGS: Nine eligible articles with 12 comparisons qualified for the final quantitative analysis. An overall decrease was noted in fasting blood glucose (weighted mean difference [WMD], -3.56 mg\/dL; 95% CI, -5.49 to -1.64; P &lt; 0.001), homeostatic model assessment for insulin resistance (WMD, -1.168 mm; 95% CI, -2.001 to -0.33; P = 0.006), insulin (WMD, -2.26 units; 95% CI, -4.35 to -0.18; P = 0.033), and glycosylated hemoglobin (WMD, -0.41%; 95% CI, -0.54 to -0.29; P &lt; 0.001) after vitamin D administration in postmenopausal women. In subgroup analyses, a notable decrease in fasting blood glucose was detected when the intervention course was &gt;6 months and dosage &lt;=1000 IU\/d (WMD, -3.48 mg\/dL). The present study showed that vitamin D was not associated with body mass index, body weight, or waist circumference in postmenopausal women. IMPLICATIONS: Vitamin D is beneficial for glucose markers but not obesity in postmenopausal women. An individualized dosage regimen of vitamin D should be followed depending on the clinical outcome target of postmenopausal women.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication:Systematic Review Author(s):Hao, Lei; Lu, Aiyangzi; Gao, Hui; Niu, Jianfei; Prabahar, Kousalya; *Seraj, Shaikh Sanjid; Pan, Yongmei. Citation:Clinical Therapeutics. 2023 Sep;45(9):913-920 Abstract:PURPOSE: The effect of vitamin D effect on glucose markers and obesity in postmenopausal women remains controversial.<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2023\/10\/30\/the-effects-of-vitamin-d-on-markers-of-glucose-and-obesity-in-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials-2023\/\">Read more <span class=\"screen-reader-text\">The Effects of Vitamin D on Markers of Glucose and Obesity in Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials (2023)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[1029,986],"class_list":["post-7669","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-1029","tag-obstetrics-and-gynaecology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=7669"}],"version-history":[{"count":2,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7669\/revisions"}],"predecessor-version":[{"id":9472,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/7669\/revisions\/9472"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=7669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=7669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=7669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}