{"id":8810,"date":"2025-07-29T08:31:12","date_gmt":"2025-07-29T07:31:12","guid":{"rendered":"https:\/\/www.library.sath.nhs.uk\/research\/?p=8810"},"modified":"2025-07-29T08:31:12","modified_gmt":"2025-07-29T07:31:12","slug":"complicated-pyelonephritis-leading-to-vertebral-osteomyelitis-diagnostic-and-therapeutic-considerations-2025","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2025\/07\/29\/complicated-pyelonephritis-leading-to-vertebral-osteomyelitis-diagnostic-and-therapeutic-considerations-2025\/","title":{"rendered":"Complicated Pyelonephritis Leading to Vertebral Osteomyelitis: Diagnostic and Therapeutic Considerations (2025)"},"content":{"rendered":"\n<p><strong>Type of publication:<\/strong><\/p>\n\n\n\n<p>Journal article<\/p>\n\n\n\n<p><strong>Author(s):<\/strong><\/p>\n\n\n\n<p>*Ibraheem, Mustafa; *Al-Rubaye, Rafal; *Tanswell, Ian<\/p>\n\n\n\n<p><strong>Citation:<\/strong><\/p>\n\n\n\n<p>Cureus. 17(5):e84838, 2025 May.<\/p>\n\n\n\n<p><strong>Abstract:<\/strong><\/p>\n\n\n\n<p>This case illustrates the significant progression of pyelonephritis to vertebral osteomyelitis secondary to Escherichia coli bacteraemia, highlighting the potential for hematogenous dissemination from urinary<br>tract infections to the spine. A female patient in her 60s initially presented with fever, nausea, and diarrhoea, subsequently diagnosed with E. coli bacteraemia from pyelonephritis. Despite initial clinical<br>improvement with intravenous and oral antibiotics, her condition deteriorated over three hospital admissions, progressing to L1\/L2 vertebral osteomyelitis complicated by bilateral psoas and epidural<br>abscesses. Her functional status markedly declined from independent ambulation to requiring assistance for mobilization. This case emphasizes critical lessons regarding the complexity of determining optimal<br>antibiotic therapy duration, especially when complicated by abscess formation and recurrent bacteraemia. It further underscores limitations associated with early transitions from intravenous to oral antibiotics in<br>complicated vertebral infections, advocating heightened clinical vigilance and a multidisciplinary approach to prevent diagnostic delays and severe functional impairment.<\/p>\n\n\n\n<p><strong>DOI:&nbsp;<\/strong>10.7759\/cureus.84838<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cureus.com\/articles\/363566-complicated-pyelonephritis-leading-to-vertebral-osteomyelitis-diagnostic-and-therapeutic-considerations#!\/\" target=\"_blank\" rel=\"noreferrer noopener\">Link to full-text<\/a> [open access - no password required]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *Ibraheem, Mustafa; *Al-Rubaye, Rafal; *Tanswell, Ian Citation: Cureus. 17(5):e84838, 2025 May. Abstract: This case illustrates the significant progression of pyelonephritis to vertebral osteomyelitis secondary to Escherichia coli bacteraemia, highlighting the potential for hematogenous dissemination<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2025\/07\/29\/complicated-pyelonephritis-leading-to-vertebral-osteomyelitis-diagnostic-and-therapeutic-considerations-2025\/\">Read more <span class=\"screen-reader-text\">Complicated Pyelonephritis Leading to Vertebral Osteomyelitis: Diagnostic and Therapeutic Considerations (2025)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[1001,200],"tags":[1085,1002],"class_list":["post-8810","post","type-post","status-publish","format-standard","hentry","category-open-access","category-staff-publication","tag-1085","tag-gold-open-access"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/8810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=8810"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/8810\/revisions"}],"predecessor-version":[{"id":8811,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/8810\/revisions\/8811"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=8810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=8810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=8810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}