{"id":902,"date":"2014-12-11T16:06:32","date_gmt":"2014-12-11T16:06:32","guid":{"rendered":"http:\/\/library.sath.nhs.uk\/intelligence\/?p=902"},"modified":"2022-09-01T12:31:22","modified_gmt":"2022-09-01T11:31:22","slug":"diagnostic-accuracy-of-point-of-care-tests-for-detecting-albuminuria-a-systematic-review-and-meta-analysis-2014","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2014\/12\/11\/diagnostic-accuracy-of-point-of-care-tests-for-detecting-albuminuria-a-systematic-review-and-meta-analysis-2014\/","title":{"rendered":"Diagnostic accuracy of point-of-care tests for detecting albuminuria: A systematic review and meta-analysis  (2014)"},"content":{"rendered":"<p> <strong>Type of publication:<\/strong><br \/> Journal article<\/p>\n<p><strong>Author(s):<\/strong><br \/> *McTaggart M.P., Newall R.G., Hirst J.A., Bankhead C.R., Lamb E.J., Roberts N.W., Price C.P.<\/p>\n<p><strong>Citation:<\/strong><br \/> Annals of Internal Medicine, April 2014, vol.\/is. 160\/8(550-557), 0003-4819;1539-3704 (15 Apr 2014)<\/p>\n<p><strong>Abstract:<\/strong><br \/> Experts recommend screening for albuminuria in patients at risk for kidney disease. Purpose: To systematically review evidence about the diagnostic accuracy of point-of-care (POC) tests for detecting albuminuria in individuals for whom guidelines recommend such detection. Data Sources: Cochrane Library, EMBASE, Medion database, MEDLINE, and Science Citation Index from 1963 through 5 December 2013; hand searches of other relevant journals; and reference lists. Study Selection: Cross-sectional studies, published in any language, that compared the accuracy of machine-read POC tests of urinary albumin-creatinine ratio with that of laboratory measurement. Data Extraction: Two independent reviewers extracted study data and assessed study quality using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool. Data Synthesis: Sixteen studies (n = 3356 patients) that evaluated semiquantitative or quantitative POC tests and used random urine samples collected in primary or secondary ambulatory care settings met inclusion criteria. Pooling results from a bivariate randomeffects model gave sensitivity and specificity estimates of 76% (95% CI, 63% to 86%) and 93% (CI, 84% to 97%), respectively, for the semiquantitative test. Sensitivity and specificity estimates for the quantitative test were 96% (CI, 78% to 99%) and 98% (CI, 93% to 99%), respectively. The negative likelihood ratios for the semiquantitative and quantitative tests were 0.26 (CI, 0.16 to 0.40) and 0.04 (CI, 0.01 to 0.25), respectively. Limitation: Accuracy estimates were based on data from singlesample urine measurement, but guidelines require that diagnosis of albuminuria be based on at least 2 of 3 samples collected in a 6-month period. Conclusion: A negative semiquantitative POC test result does not rule out albuminuria, whereas quantitative POC testing meets required performance standards and can be used to rule out albuminuria.<\/p>\n<p><strong>Link to more details or full-text: <a href=\"Hepatology\" target=\"_blank\" rel=\"noopener\">Hepatology<\/a><\/strong><\/p>\n<p> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *McTaggart M.P., Newall R.G., Hirst J.A., Bankhead C.R., Lamb E.J., Roberts N.W., Price C.P. Citation: Annals of Internal Medicine, April 2014, vol.\/is. 160\/8(550-557), 0003-4819;1539-3704 (15 Apr 2014) Abstract: Experts recommend screening for albuminuria in<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2014\/12\/11\/diagnostic-accuracy-of-point-of-care-tests-for-detecting-albuminuria-a-systematic-review-and-meta-analysis-2014\/\">Read more <span class=\"screen-reader-text\">Diagnostic accuracy of point-of-care tests for detecting albuminuria: A systematic review and meta-analysis  (2014)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[458,292,1024],"class_list":["post-902","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-458","tag-renal-disease","tag-systematic-review"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=902"}],"version-history":[{"count":2,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/902\/revisions"}],"predecessor-version":[{"id":7074,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/902\/revisions\/7074"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}