{"id":908,"date":"2014-12-12T16:18:07","date_gmt":"2014-12-12T16:18:07","guid":{"rendered":"http:\/\/library.sath.nhs.uk\/intelligence\/?p=908"},"modified":"2016-10-31T13:26:04","modified_gmt":"2016-10-31T13:26:04","slug":"nephrotic-range-proteinuria-on-interferon-beta-treatment-immune-induced-glomerulonephritis-or-other-pathway-2014","status":"publish","type":"post","link":"https:\/\/www.library.sath.nhs.uk\/research\/2014\/12\/12\/nephrotic-range-proteinuria-on-interferon-beta-treatment-immune-induced-glomerulonephritis-or-other-pathway-2014\/","title":{"rendered":"Nephrotic-range proteinuria on interferon-beta treatment: Immune-induced glomerulonephritis or other pathway?  (2014)"},"content":{"rendered":"<p> <strong>Type of publication:<\/strong><br \/> Journal article<\/p>\n<p><strong>Author(s):<\/strong><br \/> *Yuste C., *Rapalai M., *Pritchard B.A., *Jones T.J., Tucker B., *Ramakrishna S.B.<\/p>\n<p><strong>Citation:<\/strong><br \/> Clinical Kidney Journal, April 2014, vol.\/is. 7\/2(190-193), 2048-8505;2048-8513 (April 2014)<\/p>\n<p><strong>Abstract:<\/strong><br \/> We present a case report of a 37-year-old woman with multiple sclerosis (MS) who developed nephrotic-range proteinuria secondary to membrano proliferative glomerulonephritis (MPGN)-like disease with mesangial C3 deposition without evidence of immune-complex deposition in the context of long-term interferon-beta (IFN-beta) therapy. The complete remission of proteinuria following cessation of IFN-beta, strongly suggests causality. To our knowledge, this is the second case report of MPGN associated with IFN-beta use. This being the case, the negative immune screen, normal inflammatory markers and the absence of immune complex deposits would imply a different pathway to that previously suggested.<\/p>\n<p><strong>Link to more details or full-text: <a href=\"\" target=\"_blank\"><\/a><\/strong><\/p>\n<p> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Type of publication: Journal article Author(s): *Yuste C., *Rapalai M., *Pritchard B.A., *Jones T.J., Tucker B., *Ramakrishna S.B. Citation: Clinical Kidney Journal, April 2014, vol.\/is. 7\/2(190-193), 2048-8505;2048-8513 (April 2014) Abstract: We present a case report of a 37-year-old woman with<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/www.library.sath.nhs.uk\/research\/2014\/12\/12\/nephrotic-range-proteinuria-on-interferon-beta-treatment-immune-induced-glomerulonephritis-or-other-pathway-2014\/\">Read more <span class=\"screen-reader-text\">Nephrotic-range proteinuria on interferon-beta treatment: Immune-induced glomerulonephritis or other pathway?  (2014)<\/span><span class=\"meta-nav\"> &#8250;<\/span><\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","footnotes":""},"categories":[200],"tags":[458,298],"class_list":["post-908","post","type-post","status-publish","format-standard","hentry","category-staff-publication","tag-458","tag-nephrology"],"_links":{"self":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/comments?post=908"}],"version-history":[{"count":1,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/908\/revisions"}],"predecessor-version":[{"id":1480,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/posts\/908\/revisions\/1480"}],"wp:attachment":[{"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/media?parent=908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/categories?post=908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.library.sath.nhs.uk\/research\/wp-json\/wp\/v2\/tags?post=908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}