Type of publication:
Conference abstract
Author(s):
*Jones A.; *Basavaraju N.; *Cane C.; *Moulik P.
Citation:
Diabetes Technology and Therapeutics. Conference: Advanced Techologies and Treatments for Diabetes Conference, ATTD 2024. Virtual. 26(Supplement 2) (pp A326), 2024. Date of Publication: 01 Feb 2024.
Abstract:
Background and Aims: Patients with longstanding T1DM tend to have more glycaemic variability. Patient perceptions towards chronic disease change over time. We examined outcomes in patients on CSII with different DM durations. Method(s): A single adult service outcome database of T1DM patients was analysed for Hba1c, %Time in range(%TIR), %hypoglycaemia(%hypo). For Hybrid closed loop(HCL) patients, Diabetes Treatment satisfaction Questionnaire(DTSQ), Type 1 Diabetes Distress score(T1DDS), Hypoglycaemia fear survey(HypoFS) and Insulin dosing systems, perceptions, ideas, reflections and expectations(INSPIRE) scores were analysed. Results were compared across different disease duration groups. Result(s): A cohort of 302 patients with T1DM were studied. 218 were on HCL, 21 partial closed loop and 63 were nonclosed loop CSII. All were on CGM. Mean diabetes duration was 25 years (range 2-61), male:female 43:57. Mean Hba1c(53.8mmol/mol), %TIR(68.7%) and %hypo(1.79%) were similar except 21-30year duration group who had better Hba1c and TIR. Correlation(r) for Hba1c(r = -0.111,p = 0.055), TIR(r = 0.206, p < 0.001) and %hypo(r = -0.106, p = 0.067) suggest better outcomes with longer duration of diabetes. HypoFS(r = -0.169,p = 0.016) and T1DDS(r = -0.192,p = 0.006) scores correlated inversely, DTSQ(r = 0.148, p = 0.035) positively and INSPIRE(r = -0.127, p = 0.069) did not correlate with diabetes duration. Conclusion(s): CSII and CGM glycaemic outcomes were similar in patients with all diabetes durations, highest in the 20- 30 years duration group. Reasons for this remains uncertain. Longer duration correlated with better outcomes on Hba1c, TIR and satisfaction scores. Hypo fear and diabetes distress was greater with shorter duration though hypo frequency was not statistically correlated to diabetes duration. These may be due to human factors, better disease acceptance and perceptions with longer duration.
