Type of publication:
Poster presentation
Author(s):
Lei I.I.; Parisi I.; Bhandare A.; Perez F.; Lee T.; Shehkar C.; McStay M.; Anderson S.; Watson A.; Conlin A.; Badreldin R.; Malik K.; Jacob J.; Dixon A.; *Butterworth J.; Parsons N.; Koulaouzidis A.; Arasaradnam R.
Citation:
Gut. Conference: BSG Annual Meeting, BSG LIVE 2025. Glasgow United Kingdom. 74(Supplement 1) (pp A269-A270), 2025. Date of Publication: 01 Jun 2025.
Abstract:
Background Colon capsule endoscopy (CCE) has emerged as a non-invasive alternative to traditional colonoscopy for low-risk patients. However, its adoption is limited by low completion rates and the inability to perform biopsies or polyp removal, often resulting in CCE-to-conventional colonoscopy conversion (CCC). This conversion carries financial implications, contributes to patient dissatisfaction due to repeated procedures, and imposes a potential environmental burden from increased hospital visits. Objective(s) The aim is to identify the factors that predict issues with bowel cleansing, capsule excretion rates, pathology detection, and the need for CCC. Methods In this prospective analysis of the CESCAIL study (November 2021-June 2024), 603 patients who underwent CCE were included. Predictive factors-including patient demographics, comorbidities, medications, and laboratory results-were analysed across symptomatic and surveillance groups. Statistical techniques such as LASSO regression, linear regression, and logistic regression were applied. Results Among the 603 participants analyzed, elevated f-Hb levels (OR=1.48, 95% CI: 1.18-1.86, p=0.0002) and smoking (OR=1.44, 95% CI: 1.01-2.11, p=0.047) were significantly associated with CCE-to-conventional colonoscopy conversion (CCC). However, an AUC of 0.62 after adjusting for confounders suggests f-Hb is a weak predictor of CCC. Diabetes was linked to poor bowel preparation (OR=0.40, 95% CI: 0.18-0.87, p=0.022). Alcohol use (p=0.004), smoking (p=0.003), and psychological conditions (p=0.001) were significantly associated with an increased polyp count, while haemoglobin levels (p=0.046) showed a marginal negative association with polyp numbers. Additionally, antidepressants (p=0.003) were associated with larger polyps, whereas betablockers (p=0.001) were linked to smaller polyps. Conclusion Non-smokers with lower f-Hb levels are less likely to require CCC. Effective patient selection criteria are essential for minimising conversion rates and improving the efficiency of CCE services. These findings highlight the need for validation across diver
DOI: 10.1136/gutjnl-2025-BSG.428
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