Author: Jason Curtis

Magtrace Can Sustainably Improve Theatre Efficiency, Operative Capacity, and Patient Experience (2024)

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Type of publication:

Conference abstract

Author(s):

*Lake B.; *Wilson M.; *Appleton D.

Citation:

Annals of Surgical Oncology. Conference: 25th American Society of Breast Surgeons Annual Meeting, ASBrS 2024. Orlando, FL United States. 31(Supplement 2) (pp S498), 2024. Date of Publication: 01 Jun 2024.

Abstract:

Background/Objective: Magtrace is an iron oxide liquid which has revolutionized sentinel lymph node biopsy treatment for breast cancer. It has a flexible injection window which allows patients to have the injection prior to the day of surgery at a convenient time for both the patient and the provider and removes the need for nuclear medicine completely. Magtrace was reviewed by the National Institute for Health and Care Excellence in October 2022 (MTG72) and they highlighted that Magtrace has the potential to reduce cost based on an expectation that its usage would enable hospitals to perform additional sentinel node biopsies due to improved operating room utilization. The National Institute for Health and Care Excellence (NICE) provides national guidance and advice to improve health and social care in the UK. This guidance is the gold standard for advice for breast cancer treatment. Our team designed a study to investigate the "additive effect" of Magtrace in improving theatre efficiency, operative capacity, and patient experience (Presented at European Society of Surgical Oncology, to be published in European Journal of Surgical Oncology early 2025). The aim of this study was to assess if these previously described benefits of Magtrace by NICE are sustained in a hospital system. Method(s): All Magtrace cases for sentinel node biopsy at the Shrewsbury & Telford NHS Trust were prospectively recorded. The outcomes measured were operating room utilization, number of sentinel node biopsies performed per week, and patient satisfaction. Result(s): 150 patients undergoing a wide local excision or mastectomy received Magtrace as the sole technique for SLNB. Operating room utilization improved from 77% to 84% (with peak utilisation at 96%) due to a reduction in OR delays and improved OR flow. Previous delays were caused by patients waiting to have radioisotope injections. Significantly more sentinel node biopsies were performed per week, increasing from 6.48 per week (Pre Magtrace 2022) to 8.57 per week (Post Magtrace ) (t-value = 3.53057, p-value < 0.00041). This resulted in a net increase of 2 additional patients per week. The t-value is 3.53057. The p-value is .00041. The result is significant at p < 0.05. The study showed high patient satisfaction with 100% of patients finding injection more convenient on the day of surgery and 100% of patients would recommend Magtrace to a friend or relative. Conclusion(s): Utilising Magtrace for sentinel lymph node biopsy creates a sustained "additive effect" by improving operating room utilization, operating room capacity and demonstrates a high patient satisfaction.

DOI: 10.1245/s10434-024-15410-w

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Menopause training among obstetrics & gynaecology trainees in UK: Are we getting it right? (2024)

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Type of publication:

Conference abstract

Author(s):

*Malik N.; *Sahu B.; *Wood M.; *Afzal M.

Citation:

BJOG: An International Journal of Obstetrics and Gynaecology. Conference: RCOG 2024. Muscat Oman. 131(Supplement 5) (pp 129-130), 2024. Date of Publication: 01 Oct 2024.

Abstract:

Background: The menopause has garnered significant media attention in recent times due to the rising number of working menopausal women, accounts of women being disregarded, and anxiety surrounding the prescription and usage of hormone replacement therapy (HRT) due to lack of training and knowledge gap among physicians. It is a normal, natural, and inevitable part of ageing. Yet for too long, too many people experiencing menopause have struggled with societal stigma, inadequate diagnosis and treatment, workplace detriment and discrimination. The management of menopausal symptoms requires a comprehensive understanding and specialized training, particularly among obstetrics and gynecology trainees in UK. The national survey was conducted among obstetrics and gynecology trainees to evaluate the depth of knowledge with regards to management of menopause and menopause services provided at their hospital and training opportunities. Participants and Methods: This online Menopause Training review surveyed 103 postgraduate obstetrics and gynecology trainees in the UK from September 2023 to October 2023. The national survey was distributed to all deaneries in the UK for circulation to all their trainees via social media, WhattsApp groups and emails. The survey comprised of questions regarding trainees' level of training, country of training, menopause clinics in their hospital, their clinic regularity, and any designated lead clinician for menopause clinics in their hospital, management of menopause, the trainees' confidence advising patients with menopausal symptoms, and any benefit from their patient care. Result(s): The majority of responders 70 (68.63%) belonged to England followed by 21 (20.59%) Wales and Ireland 11 (10.78%). About 56 (54.36%) had a menopause clinic in their hospital and 46 (45.10%) responders conducting regular clinics. Approximately 44 (42.72%) had a designated lead clinician present in their hospital. Specific trust guidelines on the management of menopause were applied in 30 (29.13%). About 21 (20.39%) respondents felt confident advising patients with menopausal symptoms and 99 (96.12%) participants thought that going through additional formal menopause training could benefit patient care.It is imperative to adopt a novel pedagogical strategy for teaching menopause in healthcare curriculum. Conclusion(s): The survey emphasized that the need for ongoing evaluation and enhancement of menopause training programs for obstetrics and gynaecology trainees in the UK to ensure optimal patient care during this critical life stage.

DOI: 10.1111/1471-0528.17946

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A young lady with diabetic mastopathy (DMP): A less well-known complication of diabetes (2024)

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Type of publication:

Conference abstract

Author(s):

*Cane C.L.; *Jones A.M.; *Moulik P.K.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

A 26-year-old nulliparous female presented with a 2-week history of a right breast lump. She had type 1 diabetes for 17 years and polycystic ovaries. Her diabetes distress led to suboptimal glycaemic control. There was firm tissue under the right nipple-areola complex, and ultrasound (US) demonstrated a suspicious 43-mm mixed echogenic lesion with posterior shadowing (U4). Core biopsy revealed marked fibrosis with fibroblasts and entrapped benign breast ducts and adipose tissue. Breast ducts were highlighted by epithelial markers (AE1/3 and small P63), blood vessels by CD34, and fibroblasts and myoepithelial layers by smooth muscle actin (SMA). She was reassured; 2 years later she developed a left breast lump and 26-mm focal hypoechoic glandular lesion on US, right breast lesion unchanged. A diagnosis of DMP was made. DMP occurs in 20- to 40 year-old women with long duration of type 1 diabetes. It can occur in men rarely. It presents with a painless, hard, mobile breast lesions which are irregular. Bilateral lesions develop in 50% patients. Axillary lymphadenopathy is absent. Mammography reveals dense glandular tissue and US shows acoustic shadows behind the lesion. Core biopsy is recommended. DMP is a benign condition which may raise concerns of breast cancer. It may be associated with autoimmunity and occasionally seen in insulin treated type 2 diabetes, systemic lupus erythematosus and Hashimoto's. Microscopy shows periductal, perilobular and perivascular B-lymphocytic infiltrates with some T cells, fibroblast proliferation and collagen. Management is conservative unless a larger lesion requires excision. To date, only one case report has been published on breast cancer in a patient with DMP.

DOI: 10.1111/dme.15295

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Motivational techniques combined with unconventional medications and technology improving care in a disengaged patient with type 1 diabetes: A case study of a success story (2024)

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Type of publication:

Conference abstract

Author(s):

*Jones A.M.; *Basavaraju N.; *Moulik P.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

A 42-year-old lady with complex diabetes was diagnosed age 19 years. She went on an insulin pump (Medtronic Minimed), Hba1c was 56 mmol/mol which crept up to 72 mmol/mol. She developed hypertension, nephropathy and laser treated retinopathy. Starting Freestyle Libre with Medtronic640 improved Hba1c down to 52 mmol/mol. Her social and financial circumstances, including being a single mum, deteriorated leading to diabetes distress and burnout. Healthcare and diabetes management became a burden. Ambulatory glucose profile (AGP) showed time in range (TIR) 28%, high (H) 23%, very high (VH) 42% and Hba1c71 mmol/mol. Counselling and motivational interviewing with regular support was provided. She had stopped all medications and insisted on a pump break. Hba1c increased to 118 mmol/mol, TIR14%, H5%, VH81%, mean glucose (MG) 23.3 mmol/L. She wanted to restart the pump and it was felt on previous pump therapy she had safer glucose levels and no ketoacidosis. AGP improved with TIR29%, H18%, VH52%, MG15.4 mmol/L in 2 weeks. After 3 months, TIR was 33%, H20% VH42%, Hba1c76 mmol/mol. Weight was increasing with associated diabulimia. Dulaglutide was started after counselling. TIR51%, H16%, VH9%, level 1 hypoglycaemia11%, level 2 hypoglycaemia13%. She started HCL (Medtronic 780G with Guardian G4) and Hba1c was 45 mmol/mol, TIR66%, H18%, VH15%, level 1 hypoglycaemia1%, level 2 hypoglycaemia0%. Her weight has come down from 99 to 82 kg with BMI 31.4 kg/m2. Renal function has improved (eGFR 33 to 42 mL/min). Quality of life (QOL) assessments show great improvement. This case highlights a life plan is as important as a health plan. A motivational and supportive approach, advanced technologies and some off-license medication reduced diabetes burden and improved patient engagement.

DOI: 10.1111/dme.15296

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Discrepancies of glycated haemoglobin (HbA1c) and actual glucose: A case series with clinical scenarios (2024)

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Conference abstract

Author(s):

*Basavaraju N.; *Al-Samaraaie E.; *Moulik P.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

Introduction: HbA1c is a useful measure of glycaemic control over the preceding 3 months with an emphasis on preceding 30 days. We present four clinical scenarios that affect its reliability. Case 1: Twenty-nine-year-old female started on Dapsone for hidradenitis suppurativa. Pre-dapsone HbA1c was 38 mmol/mol and 2 years post-dapsone HbA1c <18 mmol/mol, normal fructosamine 272 mumol/L (211-328), glucose-6-phosphate dehydrogenase (G6PD) activity 12.9 IU/gHb (8.8-12.8), methaemoglobin 8.6% (0-1.5) and reticulocyte 6.5% (0.5-2.5) indicating haemolysis. Case 2: Forty-nine-year-old female with type 1 diabetes and rheumatoid arthritis started on sulfasalazine. HbA1c dropped from 65 to 30 mmol/mol, fructosamine 415 mumol/L (211-328), mildly raised reticulocyte 2.6%, haemoglobin 128 g/L (115-165) indicating mild haemolysis. Case 3: Fifty-nine-year-old male with type 2 diabetes and genetic haemochromatosis (C282Y homozygous) started venesection. HbA1c prior was 63 mmol/mol reduced to 29 mmol/mol, fructosamine 262 mumol/L and c-peptide 2760 pmol/L indicate good beta cell reserve. Case 4: Seventy-year-old female with Graves' disease, post-radioiodine hypothyroidism, HbA1c <20 mmol/mol (was 41 mmol/mol 2 years ago) as part of annual hypertension screen. Fasting glucose 6.0 mmol/L, low haemoglobin 102 g/L, high reticulocytes 9.5%, direct antiglobulin Coombs test positive indicating low HbA1c due to autoimmune haemolytic anaemia. Discussion(s): HbA1c depends on glycation of red blood cells (RBC) and is proportional to ambient glucose concentrations. Conditions that affect RBC lifespan and turnover can alter HbA1c values. Dapsone causes oxidative haemolysis as can sulfasalazine. Venesection and haemolytic anaemia shorten life span of red blood cells and duration of haemoglobin exposed to glucose in the bloodstream resulting in falsely lower HbA1c. Conclusion(s): Clinicians must be aware of conditions affecting accuracy of HbA1c and consider alternate tests including venous glucose, fructosamine, capillary glucose or continuous glucose monitoring.

DOI: 10.1111/dme.15296

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Evaluation of inpatient physiotherapy groups on functional ability, self-reported psychological scales, and length of stay (LOS) in acute stroke patients: A service review of current provision at the Princess Royal Hospital (2026)

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Type of publication:

Service evaluation report

Author(s):

*Emily Farla

Citation:

Shrewsbury and Telford Hospital NHS Trust, January 2026

Abstract:

Purpose: The Shrewsbury and Telford NHS trust’s acute stroke rehabilitation therapy
team set up weekly circuit class therapy (CCT) groups in 2024, running alongside
individual therapy (IT) to improve stroke rehabilitation. Physiotherapists, occupational
therapists, speech and language therapists and therapy support workers delivered
both methods of rehabilitation. The service aimed to provide quality therapy to
improve motor and psychological outcomes in the acute stroke population, supported
by results reported in current literature. Anecdotal evidence was obtained from
attendees that suggested CCT to be a positive addition and so a formal review was
indicated. This service review aimed to answer; does attending additional inpatient
CCT groups up to three times per week in addition to standard therapy for inpatient
stroke patients at the Princess Royal Hospital (PRH), influence motor function,
psychological wellbeing scores and impact hospital length of stay (LOS)?
Methods: The service evaluation reviewed notes retrospectively between the months
of May and July 2025. All consenting adult patients diagnosed with a stroke in the
last 30 days and admitted on to the Stroke and Rehabilitation wards at PRH who
were receiving active treatment and referred to therapy were included. The review
aimed to collect 30-50 sets of data. Notes were screened to collect inpatient
demographics; including gender, age, height, weight, diagnosis, number of groups
attended, length of stay, and discharge destination and outcome measures; Modified
Rivermead Mobility Index, Distress Thermometer, and Stroke Recovery Perception
from baseline and discharge time points. Data was inputted into Excel and SPSS to
complete descriptive and inferential analysis. Patient identifiable data was removed
to ensure anonymity throughout analysis.
Results: 38/50 stroke inpatients admitted to the stroke rehabilitation ward were found
to have complete sets of data (n=38). Of the 38 inpatients nine received IT and 19
attended IT with additional CCT groups. Significant motor improvements were seen
in both the IT and additional CCT groups. Significant increases in psychological
outcomes and self-perceived improvement scores were seen in the additional CCT
group compared to the IT group. There appeared to be no relationship between CCT
attendance and LOS.
Conclusions: This service evaluation has shown additional CCT groups delivered
alongside IT on the stroke rehabilitation unit at the PRH is a significantly better
service in terms of patient perceived improvement and psychological outcomes with
an equivalent benefit to IT for motor outcomes. Though no impact of group
attendance on LOS was seen, it may be due to the external factors delaying
discharge. The findings from this service review support continuing provision of the
CCT service and has provided data for comparison with future service reviews.
Further research is needed to understand the relationship between CCT attendance
and becoming therapy fit for discharge and the impact of inpatient total treatment
time by adding CCT to IT for achievement of stroke therapy guidance.

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High mortality following major amputation in diabetes: An analysis of risk factors and causes of death (2024)

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Type of publication:

Conference abstract

Author(s):

*Cane C.; *Beard N.; *Al-Samaraaie E.; *Basavaraju N.; *Moulik P.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

Aims: Mortality following major diabetic amputation is high. We analysed data on factors leading to mortality following major amputation. Method(s): Data on all 48 major non-traumatic diabetic lower-limb amputation between April 2022 and March 2023 were analysed in September 2023. 33 (69%) were alive and 15 (31%) had died. Result(s): 90% patients had type 2 diabetes and 67% had diabetes duration>10 years. 17 (35%) were female. 38 (80%) were between 50 and 80, 9 (18%) over 80 years old. 21 (42%) were overweight or obese. 26 (54%) had below knee amputation (BKA) and 22 (46%) above knee amputation (AKA). Half were current or ex-smokers, 58% hypertensive, 79% hyperlipidaemic or on statins, 83% on antiplatelet/anticoagulants. 27 (57%) had eGFR >60 mL/min, 17 (35%) eGFR 30-60 mL/min, 4 (8%) eGFR 15-30 mL/min and none with eGFR <15 mL/min. 37% had pre-proliferative/proliferative retinopathy or maculopathy, 28 (58%) previous foot ulcers and 19 (40%) previous amputation. 80% had neuropathy and 80% peripheral arterial disease. Cause of amputation was critical ischaemia in 27 (56%), sepsis/spreading gangrene in 17 (36%). 10 patients died in hospital and 5 in the community. Cause of death was cardiorespiratory in 6 (40%), sepsis related to DFU in 2 (13%), sepsis unrelated to DFU in 3 (20%), old age/dementia in 2 (13%) and unknown in 2 (13%). Mortality was similar in BKA and AKA. Mann-Whitney test with Monte Carlo correction suggested age >40 at diagnosis of diabetes, advanced nephropathy and retinopathy additionally predicted mortality. Conclusion(s): A third of patients had died within a year following major amputation. Majority were older patients with multiple risk factors contributing both to amputation and mortality, but additional predictors of mortality were nephropathy and retinopathy.

DOI: 10.1111/dme.15296

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Root cause analysis of non-traumatic major amputation in diabetes in a district general hospital: Are we missing opportunities to improve care? (2024)

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Type of publication:

Conference abstract

Author(s):

*Beard N.B.; *Basavaraju N.B.; *Al-Samaraaie E.A.; *Cane C.C.; *Moulik P.M.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

Background: There is concern that Shropshire and Telford have significantly higher minor and major diabetic foot amputations. Method(s): Data on all 48 major non-traumatic lower limb amputation in diabetes were collected between April 2022 and March 2023. Indicators of care and pathways to amputation were studied. Result(s): 38 (80%) patients were between 50 and 80, 9 (18%) over 80 and 1 (2%) was less than 50 years age. 26 (54%) had below knee and 22 (46%) above knee amputation. 22 (45%) had documented diabetes foot check in the preceding year, 39 (80%) had high risk feet, 28 (58%) previous foot ulcers and 19 (40%) previous minor amputation. 23 (48%) had been seen by the foot protection team in the 8 weeks prior to amputation and 26 (54%) did not have an urgent referral to the muldisciplinary (MDT) foot clinic. 39 (80%) had neuropathy, 38 (80%) had peripheral arterial disease and 10% had Charcot's. SINBAD score was unavailable for 19 (40%) as not seen in MDT clinic, the score was 1, 2, 3, 4, 5 and 6 in 2%, 10%, 8%, 33%, 4% and 2%, respectively, in the rest. Pre-amputation x-rays were available in 54%, antibiotics given in 69%, debridement done in 33% and offloading provided in 60%. 23% had lower limb arterial bypass, 21% had angioplasty and 8% theatre-based debridement. Conclusion(s): Opportunities for improving foot care exist and could prevent or reduce major amputations as majority were in known high risk feet but did not receive NICE recommended care. A significant number of patients were admitted directly for amputation without having the benefit of amputation prevention interventions.

DOI: 10.1111/dme.15296

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Lessons from a teacher: Managing diabetic foot sepsis in the NHS under critical pressure (2024)

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Type of publication:

Conference abstract

Author(s):

*Cane C.L.; *Beard N.; *Breeze S.; *Moulik P.K.

Citation:

Diabetic Medicine. Conference: Diabetes UK Professional Conference 2024. London . 41(Supplement 1) (no pagination), 2024. Date of Publication: 01 Apr 2024.

Abstract:

A 49-year-old schoolteacher with insulin treated type 2 diabetes attended the diabetic foot clinic. Four days prior he tripped causing a left big toe superficial abrasion. He felt unwell the next day with chills. In MDT clinic, he had normal blood pressure and glucose, temperature 37.2degreeC, left hallux superficial ulcer, SINBAD score 3, cellulitis on left forefoot, neuropathy, biphasic foot pulses on doppler. The hospital was in critical incident, the patient was compliant but reluctant to come in and a decision for supervised outpatient treatment made with daily phone contact, alternate day attendance with safety netting advice to attend A&E. He was started on CGM (Freestyle Libre), oral co-amoxiclav and ciprofloxacin. Initial abnormal blood tests (WBC 18.7 x 109/L, CRP 210 mg/L, Lactate 2.4 mmol/L, Glucose 10.8 mmol/L) results improved on retesting. Sepsis symptoms were settling. After 4 days, foot doppler signals became monophasic and with tissue necrosis on the hallux though his cellulitis was settling. He was admitted briefly for intravenous antibiotics and urgent MRI angiogram (showed good anterior tibial inflow into foot). The foot is slowly healing, his foot pulse doppler signal has returned to biphasic, but there is an eschar on the left hallux and the toenail has fallen off. The case highlights the risk of capillaritis in diabetic foot sepsis which can lead to rapid tissue hypoperfusion and necrosis. Doppler signals are unreliable in presence of sepsis and tissue oedema. A virtual ward setup with intravenous antibiotics and rapid diagnostic test access is being developed before the winter bed crisis.

DOI: 10.1111/dme.15296

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Implementing the new BSE methods and reference ranges for the Proximal Ascending Aorta and the impact on downstream testing-experience of a District General Hospital (2023)

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Type of publication:

Conference abstract

Author(s):

*Doherty J.; *Ellis C.; *Lee E.;

Citation:

Echo Research and Practice. Conference: British Society of Echocardiography annual meeting 2023. Newport . 11(Supplement 1) (no pagination), 2024. Date of Publication: 01 Jul 2024.

Abstract:

Background: In 2020 the BSE updated the methods and reference values for assessing the proximal ascending aorta (PAA). It is important to quantify how implementing these methods alter the rate of 'dilated' PAAs identified by echocardiography, and how this will impact the wider service and patient pathway. Purpose(s): To compare the rate of dilated PAAs detected by the current BSE methods, and two other methods of assessing the PAA in our patient population. Method(s): All transthoracic echocardiograms where the PAA was measured between January 2018 and December 2019 were included. Studies with incomplete demographics or bicuspid aortic valves were excluded. The PAA was indexed to height (Method 1), body surface area (BSA) (Method 2) and height2.7 (Method 3), compared to the corresponding normal reference values and classified as 'dilated' or 'nondilated' accordingly. The rate of 'dilated' proximal ascending aortas were compared using Chi-squared test. Result(s): 11,828 studies were identified. 2189 were removed due to incomplete patient demographics and 27 with bicuspid aortic valves. 2710 studies were removed as Method 2 does not provide reference values for patients < 45 and Method 3 > 80 years old. 6902 studies were included in the analysis. Method 1 classified significantly more PAAs as 'dilated' (31%, AUC = 0.930) compared to Method 2 (10%, AUC = 0.841) and 3 (3%, AUC = 0.921) (X2(1, N = 6902) = 2435.8, p < 0.001). Figure 1 (abstract ABS004) A comparison of number of Proximal Ascending Aortas classified as dilated using three different methods of normalising and assessing the proximal ascending aorta to body size; Method 1-height and sex, Method 2-body surface area, age and sex and Method 3-height2.7, age and sex.*Significantly different from Method 1 (p < 0.001).**Significantly different to Method 2 (p < 0.001) Figure 2 (abstract ABS004) Receiver Operating Characteristic (ROC) curves of three methods for assessing the size of the proximal ascending aorta (PAA) on echocardiography; BSE recommended methods using height and sex (Method 1, green), body surface area, age and sex (Method 2, red) and height2.7, age and sex (Method 3, blue). Sensitivity and 1-specificty values for each method at the PAA diameter of 4 cm is plotted. Of the 6902 studies, 306 PAAs were > 4 cm. Method 1 classified all PAAs > 4 cm and 1885 < 4 cm as dilated; Method 2 classified 111 PAAs > 4 cm and 82 < 4 cm as dilated; and Method 3 classified 203 PAAs > 4 cm and 476 < 4 cm as dilated. Conclusion(s): Adopting the 2020 BSE recommended methods significantly increase the detection rate of dilated PAAs in our patient population. This will impact subsequent downstream testing, affecting resource planning and patient journey.

DOI: 10.1186/s44156-024-00053-0

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