Pleural-based giant solitary fibrous tumour with associated hypoglycaemia: unusual presentation with pulmonary hypertension in a patient with Doege-Potter syndrome (2023)

Type of publication:
Journal article

*Gohir, Qasim; Ghosh, Shilajit; *Bosher, Olivia; Crawford, Emma; *Srinivasan, Koottalai; *Moudgil, Harmesh

Clinical Medicine, Sep2023; 23(5): 518-520.

Refractory hypoglycaemia in a patient with a solitary fibrous tumour (SFT) is very rare and was first reported in 1930 independently by Doege and Potter, leading to it being named 'Doege–Potter syndrome'. Here, we report the unusual case of a 77-year-old woman with a giant solitary fibrous pleural tumour who presented with complicating pulmonary hypertension and associated heart failure with hypoglycaemia, and subsequently underwent curative resection of the pleural mass with clinical improvement.

Link to full-text [NHS OpenAthens account required]

Patients' frailty and co-morbidities do not affect short-term mortality following emergency colorectal cancer surgery (2023)

Type of publication:
Journal article

*Mak, Richard; Deckmann, Nico; Collins, Danielle; Maeda, Yasuko.

The Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh & Ireland. 2023 Sep 25.

AIM: To investigate the effects of frailty and co-morbidities on short and medium-term outcome following emergency colorectal cancer surgery. METHODS: Data of patients who underwent emergency colorectal cancer operations between January 2013 and December 2016 were reviewed retrospectively. Collected data included demographic and operative variables, clinical frailty scale (CFS), Charlson comorbidity index (CCI)
and cause of death with minimum 3 years follow-up. RESULTS: Three-hundred and six patients (median age 72, range 18-100 years) underwent emergency colorectal cancer surgery; Some 74 (24.2%) patients had metastatic cancer at the time of emergency surgery, 77 (25.2%) were frail (CFS >=4), while 118 (38.6%) were comorbid (CCI of >=8). Thirty-day mortality was 4.2% (13 patients) and a further 12 patients died within 90 days (8.2%). By 1 year 73 (23.9%) patients had died, and by 3 years 151 (49.3%) patients died. Frailty did not impact 30-day mortality (6.5% vs 3.5%, p = 0.26) but frail patients (CFS >=4) had a higher mortality rate at 90 days (16.9% vs 5.2%, p < 0.05), 1 year (37.7% vs 19.2%, p < 0.05) and 3 years (61.0% vs 45.4%, p < 0.05). Similarly, higher comorbidity (CCI >=8) did not impact 30-day mortality (5.9% vs 3.2%, p = 0.25), but they had a higher mortality rate at 90 days (14.4% vs 4.3%, p < 0.05), 1 year (40.7% vs 13.3%, p < 0.05), and 3 years (76.3% vs 32.4%, p < 0.05). CONCLUSION: Thirty-day mortality after emergency colorectal cancer surgery in frail and comorbid patients are similar to that of the general population.

Should gastric band slippage be managed with laparoscopic unclipping and re-clipping? (2023)

Type of publication:
Conference abstract

*Maharaj G.; *Jain R.; *Riera M.

14th Annual Scientific Meeting of British Obesity and Metabolic Surgery Society, BOMSS 2023

INTRODUCTION: Laparoscopic Adjustable Gastric Band (LABG) is a popular bariatric procedure. Gastric band slippage is a recognised complication. Treatment options include band removal or unclip. Subsequent re-clip/reposition of a previously unclipped band may provide further weight loss. This study aims to examine patient outcomes following un-clipping of slipped gastric bands. METHOD(S): Electronic Records of patients who underwent gastric band unclipping during a ten year period were examined. RESULT(S): 11 female patients underwent gastric band unclipping, five as emergencies. Nine patients (82%) had confirmed band slippage/pouch dilatation. Mean age at unclip was 46.5yrs. Median duration band insertion to unclip was 7yrs (range 3-11yrs). 8 patients underwent subsequent band reclip/reposition. 1 patient had attempted re-clip converted to removal. Median duration unclip to re-clip was 9months (range 4-14months). 3/8 patients with re-clipped bands had no further procedures and maintained weight loss. Of the remaining five patients, two had early removal because of acute dysphagia on days-2 and 5 post re-clipping. The other three patients eventually suffered further slippage and band intolerance. Median duration re-clip to band removal 2yrs (range 0-4yrs). Two patients were never re-clipped (one had symptomatic removal, the other is awaiting a further procedure). In total, seven bands were removed (64%). Four of these patients suffered significant weight regain, with two requiring revisional surgery. CONCLUSION(S): This study is small. However 64% of patients who underwent gastric band unclipping had subsequent removal. Hence gastric band unclipping does not appear to provide added benefit to patient care, and exposes them to additional procedures.

A Case of the Cascade Stomach; Laparoscopic Sleeve of Fundoplication (2023)

Type of publication:Conference abstract

Author(s):*Davies S.; *Maharaja G.; *Riera M.

Citation:14th Annual Scientific Meeting of British Obesity and Metabolic Surgery Society, BOMSS 2023

Abstract:A Case of the Cascade Stomach; Sleeve of Fundoplication Introduction The cascade stomach is a long standing known entity often referred to as 'cup and spill deformity' but very little is known on the management of these cases particularly surgically. Cases often present with acid reflux and vomiting due to the physiological and anatomical deformity of the stomach and are subsequently referred to the benign upper gastrointestinal/bariatric surgeon to manage. Surgical options reported in the literature are sparse but include gastropexy, laparoscopic sleeve gastrectomy and laparoscopic fundoplication. Methods We present this unusual condition as a case report, discuss the challenges in management and propose surgical management options. Conclusion Although rare this cases propose a challenge to the benign UGI surgeon as currently there is very little in the literature to support best management options. This unusual case was managed with a laparoscopic Nissen's fundoplication and we further propose that this should potentially be the standard recognised course of treatment in these cases due to the pathophysiological nature of this condition and the functional process which often leads to these patients to be high risk of acid reflux.

Improving the care of patients with obesity needing joint replacement - time for a combined ortho-bariatric approach? (2023)

Type of publication:Conference abstract

Author(s):Sinha Y.; Ikram S.; Ballinger T.; Gouveia S.; Burak M.; Wiggins T.; *Bathgate S.;

Citation:Obesity Surgery. Conference: 14th Annual Scientific Meeting of British Obesity and Metabolic Surgery Society, BOMSS 2023. Birmingham United Kingdom. 33(Supplement 1) (pp S129), 2023. Date of Publication: July 2023.

Abstract:Introduction Patients with obesity awaiting joint replacement surgery of the lower limbs may benefit from referral to weight-management services. (1) NICE provides BMI criteria for referral to tertiary bariatric services, however this does not always translate into clinical practice. (2, 3) Our aim was to assess the number and management of patients with obesity attending orthopaedic clinics for consideration of lower limb joint replacement. Methods A retrospective analysis was undertaken of all patients attending orthopaedic clinics for joint replacement secondary to osteoarthritis, in the lower limbs, at a single centre, over a two year period. Details of demographics, BMI, comorbidities and management plans were recorded from electronic patient records. Results 335 patients (60% of 558 cases) had BMI recorded and were used for subsequent analysis. 36% (n=120) of patients were eligible for referral to weight-management services. 10% (n=32) were refused joint replacement surgery due to BMI, of which 81% (n=26) were eligible for referral to weight-management services. Instead of surgery, these 32 patients were offered: physiotherapy (n=10, 38%), analgesia (n=12, 46%), non-specific weight-loss advice (n=16, 62%), GP referral for weight-loss (n=6, 23%), and tertiary service referral for weight-loss (n=2, 8%). Conclusions BMI is an important risk factor for orthopaedic operations and increased efforts should be made to record it pre-operatively. An MDT approach would capture the notable proportion of patients who are not being appropriately referred to weight-management services which may impact on their quality of life and postoperative outcomes.

Retrospective multicentre study comparing survival outcomes in chronic lymphocytic leukaemia (CLL) with genetic risk stratification (2023)

Type of publication:Conference abstract

Author(s):Qureshi I.; Mandal A.; Foster N.; Rose S.; Sharma K.; McIlroy G.; *Cherian G.; *Lane S.; Wandroo F.; Talbot G.; Pemberton N.; Parry H.; Moss P.; Paneesha S.

Citation:British Journal of Haematology. Conference: 63rd Annual Scientific Meeting of the British Society for Haematology. Birmingham United Kingdom. 201(Supplement 1) (pp 67-68), 2023. Date of Publication: April 2023.

Abstract:Purpose: This retrospective West Midlands multicentre study of CLL patients was conducted to review results of genetic testing in CLL patients and impact on survival. Method(s): 349 patients across the West Midlands were included in this retrospective study collected between December 2018 and March 2022. Clinical centres were asked to obtain data relating to the type and number of lines of treatment, overall response and reported genetic abnormalities. Treatment and response were categorised as per international workshop on chronic lymphocytic leukaemia (iwCLL) criteria.1 Genetic testing comprised fluorescence in situ hybridisation (FISH) for copy number abnormalities of 17p &11q, IgHV mutation status and Oxford Gene Technology CLL Next-Generation Sequencing (NGS) Panel to detect sequence variants in key genes associated with CLL (including NOTCH1, SF3B1, BIRC3, ATM and TP53). Patients were risk stratified into good, poor or not poor risk categories as per Rodriguez-Vicente et al.2 Statistical Analysis and Results: For 349 patients analysed, 143 (41%) patients were under active surveillance, and 206 (59%) patients received 1st line treatment. Out of the 206 patients that received 1st line treatment, 92 (44%) patients proceeded to 2nd line treatment, 31 (15%) patients proceeded to 3rd line treatment and 21 (10%) of patients required treatment beyond 3rd line Within the poor risk category, 173 patients were identified with 38 had TP53 deletion or mutation and 135 patients had other poor risk mutations such as NOTCH1, SF3B1, ATM. Statistical analysis did not show a difference in survival either from the diagnosis or from the date of NGS sample in the two groups of high-risk patients. Conclusion(s): The data identifies a cohort of patients with poor outcome that are negative for TP53 mutation, highlighting the importance of NGS in CLL patients at the point of treatment.

Acoustic Times or . . . Scan you believe it! - A quality publication. Ultrasound governance: communicating standards during a pandemic (2023)

Type of publication:Conference abstract

Author(s):*Brown H.

Citation:Ultrasound. Conference: 53rd Annual Scientific Meeting of the British Medical Ultrasound Society. Cardiff United Kingdom. 31(2) (pp NP32), 2023. Date of Publication: May 2023.

Abstract:Introducing new governance processes into a multisite ultrasound department during a pandemic led to the re-thinking of the models of communication used to share governance objectives. The introduction of peer review audit can be challenging for staff. Clear communication is vital to ensure staff are not threatened by the process and are able to use it as a learning opportunity to shape their practice and development, thereby improving patient safety. A monthly newsletter Acoustic Times was introduced to explain the processes and changes giving the opportunity to provide the evidence base and links to national guidance. Peer review audit and learning meetings were introduced and held virtually across sites to identify and share any individual or group learning points. Processes and documents were either redesigned or introduced, with supporting rationale and evidence provided through the newsletter including: evidence based protocols; standard setting; peer review audit, including supporting learning outcomes and CPD; actionable reporting; preceptorship; service user feedback; and equipment QA. Further supported learning was provided on critical reflection, specific focus on technical aspects of clinical examinations, sharing of external learning events, CPD and inhouse ultrasound training. Benefits of the newsletter include: more focus on improving consistency of practice and setting standards; faster reporting of audit findings and reaudits; and improved engagement with consultant colleagues. It also provides an accessible record of the development of governance processes which has been shared with sonographers in other organisations. Setting and communicating clearly defined quality standards and protocols is key to the design of safe working practices and patient safety in healthcare environments.1 Open and honest governance processes with clear, accessible and useable documentation are key in staff engagement and ownership of quality improvement.

An overview of bone cement: Perioperative considerations, complications, outcomes and future implications (2023)

Type of publication:Journal article

Author(s):*Patel R.; Mcconaghie G.; Webb J.; Laing G.; *Roach R.; Banerjee R.

Citation:Journal of perioperative practice 2023. Date of Publication: 26 May 2023. [epub ahead of print]

Abstract:Polymethyl methacrylate is commonly known as bone cement and is widely used for implant fixation in various orthopaedic arthroplasty and trauma surgery. The first bone cement use in orthopaedics is widely accredited to the famous English surgeon, John Charnley, who in 1958, used it for total hip arthroplasty. Since then, there have been many developments in cementing techniques in arthroplasty surgery. This overview aims to cover the perioperative considerations of bone cement, including cementing techniques, current outcomes and complications such as bone cement implantation syndrome. The overview will additionally consider future developments involving bone cement in orthopaedic arthroplasty.

Evaluating the lasting effects of teaching sudden unexpected death in infancy and childhood (SUDIC) through simulation (2023)

Type of publication:Conference abstract

Author(s):Layman S.; Beatty C.; Williams C.; *Belfitt A.; Copeman A.

Citation:Archives of Disease in Childhood. Conference: Royal College of Paediatrics and Child Health Conference, RCPCH 2023. Glasgow United Kingdom. 108(Supplement 2) (pp A276-A277), 2023. Date of Publication: July 2023.

Abstract:Objectives Paediatricians play a vital role in managing and facilitating investigations in sudden unexpected death in infancy or childhood (SUDIC). SUDIC is a rare occurrence, and many paediatric trainees and consultants have very little experience of the process. The SUDIC simulation course was created due to recommendations by The Kennedy Report. The aim of the course was to bridge the gap between knowledge and clinical experience for senior paediatric trainees and consultants in the West Midlands in managing SUDIC. To assess the longevity of learning from the course, a survey was disseminated to all previous candidates. Its aim was to understand how important the simulation course had been in improving paediatricians' confidence and understanding of the SUDIC process when they were involved in a SUDIC after attending the course. Methods Candidate sign-in sheets were retrospectively reviewed for the 17 SUDIC courses run since January 2016. 195 previous candidates were invited to complete a survey via email. Our aim was to evaluate how the course had impacted subsequent experience of the SUDIC process. Specific questions were included to assess how confident candidates had been in various roles in the SUDIC process using a combination of multiple-choice, free-text, and Likert scales. Results 43% of respondents had been a senior paediatric registrar when they attended. Other candidates were consultants, nurses, or more junior paediatricians. 43% had attended between 1-5 SUDIC events since the course, with 4% having attended more than 10. 47% had been involved in examining the body. 40% involved in an unsuccessful resuscitation and SUDIC investigations, and 43% explained the SUDIC process to bereaved parents. 100% agreed that the course had improved their confidence in explaining the SUDIC process, taking a SUDIC history and performing SUDIC investigations. 94% felt confident in contributing to the child death process with 89% feeling confident in examining the body. Candidates particularly valued the multi-professional approach to the course, especially working with police officers. With further thematic analysis of free text responses, candidates most often reported lasting benefits to supporting and communicating with the family, and understanding the practicalities of the SUDIC process. Conclusion Participation in a SUDIC simulation course is an important educational experience, which continues to be relevant to participants and their clinical practice many years after they have attended. Our survey suggests that simulation-based education is an excellent modality to facilitate learning around the SUDIC process for paediatricians and other health professionals involved.

Link to full-text (NHS OpenAthens account required)

Comparison of the Efficacy of Male Sexual Activity Versus Alpha-Blockers in the Expulsion of Distal Ureteric Stones: A Systematic Review and Meta-Analysis (2021)

Type of publication:Systematic Review

Author(s):Juman, Charlotte; Bruce, Angus; Kwan, Tsun Y; *Krishan, Anil; Ehsanullah, Syed Ali Mohsin; Khashaba, Shehab; Rafie, Mohamed A.

Citation:Cureus. 13(11):e19347, 2021 Nov.

Abstract:Globally, the prevalence of urolithiasis is increasing, with limited effective treatment options. Though debate exists within the literature, the use of medical expulsive therapy (MET) for distal ureteric stones in the form of alpha-blockers is commonplace. Alpha-blockers work via the inhibition of norepinephrine, resulting in a small degree of distal ureteric relaxation. Nitric oxide (NO), the main neurotransmitter involved in penile erection, causes smooth muscle relaxation of the distal ureter. It is hypothesised that these alternative pathways may achieve the same desire clinical effect. To our knowledge, this is the first meta-analysis comparing the efficacy of male sexual activity, in the form of intercourse or masturbation, to alpha-blockers in the expulsion of ureteric stones. We conducted a comprehensive search of electronic databases (PubMed, MEDLINE, EMBASE, SCOPUS, CENTRAL and Google Scholar), identifying studies comparing male sexual activity versus alpha-blockers, in male patients with distal ureteric stones. The Cochrane risk-of-bias tool was used to assess the included studies. For data analysis, a random effects model was used in the event of significant heterogeneity (>75%), with fixed-effects modelling in the event of low-moderate heterogeneity. A search of electronic databases found three randomised control trials (RCTs), enrolling a total of 262 patients. There was no statistically significant difference observed when patients engaged in sexual activity rather than alpha-blocker, when looking at stone expulsion rate at two weeks (P=0.36), expulsion rate at four weeks (P=0.57), or the mean stone expulsion time (P=0.21). Furthermore, there was no significant difference observed when looking at analgesic requirements (P=0.43), or the requirement for additional procedures (P=0.57). Our meta-analysis demonstrated that male sexual activity as an alternative therapy for distal ureteric stones had comparable outcomes to the use of alpha-blocker, proving a viable alternative therapy in those patients wishing to avoid pharmacological management.

Link to full-text (open access - no password required)