Quantifying association of early proteinuria and estimated glomerular filtration rate changes with long-term kidney failure in C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis using the United Kingdom RaDaR Registry (2025)

Type of publication:

Journal article

Author(s):

Downward L.; Proudfoot C.; Webb N.J.A.; Abat S.; Adalat S.; Agbonmwandolor J.; Ahmad Z.; Alejmi A.; Almasarwah R.; Annear N.; Araujo M.; Asgari E.; Ayers A.; Baharani J.; Balasubramaniam G.; Jo-Bamba Kpodo F.; Bailey L.; Bansal T.; Barratt A.; Barratt J.; Bates M.; Bayne N.; Bendle J.; Benyon S.; Bergmann C.; Bhandari S.; Bingham C.; Boddana P.; Bond S.; Braddon F.; Bramham K.; Branson A.; Brearey S.; Bridgett V.; Brocklebank V.; Budwal S.; Byrne C.; Cairns H.; Camilleri B.; Campbell G.; Capell A.; Carmody M.; Carson M.; Cathcart T.; Catley C.; Cesar K.; Chan M.; Chea H.; Chess J.; Cheung C.K.; Chick K.-J.; Chitalia N.; Christian M.; Chrysochou T.; Clark K.; Clayton C.; Clissold R.; Cockerill H.; Coelho J.; Colby E.; Colclough V.; Conway E.; Cook H.T.; Cook W.; Cooper T.; Coward R.J.; Crosbie S.; Cserep G.; Date A.; Davidson K.; Davies A.; Dhaun N.; Dhaygude A.; Diskin L.; Dixit A.; Doctolero E.A.; Dorey S.; Downard L.; Drayson M.; Dreyer G.; Dutt T.; Etuk K.; Evans D.; Finch J.; Flinter F.; Fotheringham J.; Francis L.; Gallagher H.; Game D.; Garcia E.L.; Gavrila M.; Gear S.; Geddes C.; Gilchrist M.; Gittus M.; Goggolidou P.; Goldsmith C.; Gooden P.; Goodlife A.; Goodwin P.; Grammatikopoulos T.; Gray B.; Griffith M.; Gumus S.; Gupta S.; Guzman R.; Hamilton P.; Hamrang-Yousefi S.; Harper L.; Harris T.; Haskell L.; Hayward S.; Hegde S.; Hendry B.; Hewins S.; Hewitson N.; Hillman K.; Hiremath M.; Howson A.; Htet Z.; Huish S.; Hull R.; Humphries A.; Hunt D.P.J.; Hunter K.; Hunter S.; Ijeomah-Orji M.; Inston N.; Jayne D.; Jenfa G.; Jenkins A.; Johnson S.; Jones C.A.; Jones C.; Jones A.; Jones R.; Kamesh L.; Kanigicherla D.; Frankl F.K.; Karim M.; Kaur A.; Kavanagh D.; Kearley K.; Kerecuk L.; Khwaja A.; King G.; Kislowska E.; Klata E.; Kokocinska M.; Koziell A.; Lambie M.; Lawless L.; Ledson T.; Lennon R.; Levine A.P.; Maggie Lai L.W.; Lipkin G.; Lovitt G.; Lyons P.; Mabillard H.; Mackintosh K.; Mahdi K.; Maher E.; Marchbank K.J.; Mark P.B.; Masoud S.; Masunda B.; Mavani Z.; Mayfair J.; McAdoo S.; Mckinnell J.; Melhem N.; Meyrick S.; Moochhala S.; Morgan P.; Morgan A.; Muhammad F.; Murray S.; Novobritskaya K.; Ong A.C.M.; Oni L.; Osmaston K.; Padmanabhan N.; Parkes S.; Patrick J.; Pattison J.; Paul R.; Percival R.; Perkins S.J.; Persu A.; Petchey W.G.; Pickering M.C.; Pinney J.; Pitcher D.; Plumb L.; Plummer Z.; Popoola J.; Post F.; Power A.; Pratt G.; Pusey C.; Pywell S.; Rabara R.; Rabuya M.; Raju T.; Javier C.; Roberts I.S.D.; Roufosse C.; Rumjon A.; Salama A.; Saleem M.; Sandford R.N.; *Sandu K.S.; Sarween N.; Sayer J.A.; Sebire N.; Selvaskandan H.; Shah S.; Sharma A.; Sharples E.J.; Sheerin N.; Shetty H.; Shroff R.; Simms R.; Sinha M.; Sinha S.; Smith K.; Smith L.; Srivastava S.; Steenkamp R.; Stott I.; Stroud K.; Swallow D.; Swift P.; Szklarzewicz J.; Tam F.; Tan K.; Taylor R.; Tischkowitz M.; Thomas K.; Tse Y.; Turnbull A.; Turner A.N.; Tyerman K.; Usher M.; Venkat-Raman G.; Walker A.; Walsh S.B.; Waters A.; Watt A.; Webster P.; Wechalekar A.; Welsh G.I.; West N.; Wheeler D.; Wiles K.; Willcocks L.; Williams A.; Williams E.; Williams K.; Wilson D.H.; Wilson P.D.; Winyard P.; Wong E.; Wong K.; Wood G.; Woodward E.; Woodward L.; Woolf A.; Wright D.; Wong E.K.S.; Gale D.P.

Citation:

Kidney International. 108(3) (pp 455-469), 2025. Date of Publication: 01 Sep 2025.

Abstract:

Introduction: C3 glomerulopathy (C3G) and immune-complex membranoproliferative glomerulonephritis (IC-MPGN) are rare disorders that frequently result in kidney failure over the long-term. Presently, there are no disease-specific treatments approved for these disorders, although there is much interest in the therapeutic potential of complement inhibition. However, the limited duration and necessarily small size of controlled trials means there is a need to quantify how well short-term changes in estimated glomerular filtration rate (eGFR) and proteinuria predict the clinically important outcome of kidney failure. Method(s): We address this using longitudinal data from the UK Registry of Rare Kidney Diseases (RaDaR) involving retrospective and prospective data collection with linkage to hospital laboratories via automated feeds of 371 patients. Analyses of kidney survival were conducted using Kaplan-Meier and Cox regression with eGFR slope estimated using linear mixed models. Result(s): In a median of 11.0 (inter quartile range 7.4-15.1) years follow-up, 148 patients (40%) reached kidney failure. There was no significant difference in progression to kidney failure between C3G and IC-MPGN groups. Baseline urine protein-creatinine ratio (UPCR), although high, was not associated with kidney failure in either group. Two-year eGFR slope had a modest association with kidney failure. In contrast, both 20%-50% and 50 mg/mmol reductions in UPCR between 0-12 months were associated with lower kidney failure risk in both groups. Notably, those with a UPCR under 100 mg/mmol at 12 months had a substantially lower risk of kidney failure (hazard ratio 0.10 (95% confidence interval 0.03-0.30). Conclusion(s): Overall, proteinuria a short time after diagnosis is strongly associated with long-term outcomes and a UPCR under 100 mg/mmol at one year is associated with a substantially lower kidney failure risk.

DOI: 10.1016/j.kint.2025.06.003

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Enhancing Sustainability in Endoscopically Assisted Naso-Jejunal Tube Insertion - A Novel Approach (2025)

Type of publication:

Poster presentation

Author(s):

Bhargava K.; Bhargava C.; Dimitriadis S.; Sawyer M.; *Desai K.; Shekhar C.

Citation:

Gut. Conference: BSG Annual Meeting, BSG LIVE 2025. Glasgow United Kingdom. 74(Supplement 1) (pp A287), 2025. Date of Publication: 01 Jun 2025.

Abstract:

Introduction Due to the high caseload and heavy reliance on plastic predominant equipment in endoscopy, single use consumables remain a significant contributor to endoscopy related CO2 emissions (CO2e). Naso-jejunal tube (NJT) is a flexible tube that enables post-pyloric feeding. Conventionally, NJT insertion is performed endoscopically utilising consumables (e. g. single use laryngoscopes). We aimed to calculate and compare the CO2e of the standard NJT insertion process (SNIP) and a proposed innovative NJT insertion process (INIP). Method We dismantled each consumable used in the SNIP and INIP and calculated their associated CO2e by multiplying their weights by pre-established greenhouse gas emission factors published by the government of the United Kingdom. We further contacted relevant manufacturers to include emissions related to packaging, travel and transport, where possible. Results The SNIP emitted 1.327kg CO2e, while the INIP emitted 0.113kg CO2e – yielding an 11-times lower carbon footprint. The most significant contributor to SNIP emissions was the utilisation of the single use laryngoscope (0.838kg CO2e). In contrast, the INIP enabled NJT insertion, independent of conventional single-use instrumentation. Conclusion Implementing the INIP approach for NJT insertions for hospital and community-based patients would provide a sustainable alternative to existing procedural standards. Based on current data, utilising the INIP as standard practice would reduce 5827.2kg of NJT associated CO2e per year, in the UK. Further epidemiological research on populations receiving enteral feeding is required to more accurately evaluate the INIP's environmental impact.

DOI: 10.1136/gutjnl-2025-BSG.454

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Diagnostic Capabilities of MRI and CT in Evaluating Dizziness: A Systematic Review of Acute Cases in the ED (2025)

Type of publication:

Journal article

Author(s):

Ali Mohammed, Elsuha Elgassim; Alzain Ali, Mohamed Almogtaba Mohamed; Eltayeb, Ethar; Saidahmed Ahmed, Lobaba Mubarak; *Ahmed Dafaalla, *Dalia Hamdan; Mohammed Elsheikh, Mohammed Omer; M Osman, Hanady Me.

Citation:

Cureus. 17(7):e88057, 2025 Jul.

Abstract:

Dizziness is a common reason for ED visits, posing diagnostic challenges due to its broad range of potential causes, from benign vestibular conditions to critical cerebrovascular events. Although CT scans are often used to quickly assess for intracranial hemorrhage, MRI provides greater accuracy for identifying strokes in the posterior circulation. Differences in imaging practices and uncertainty about the most effective approach highlight the need for a thorough evaluation of these modalities. This narrative systematic review examined the diagnostic performance of MRI and CT in assessing patients presenting with acute dizziness in ED settings, focusing on detection rates and clinical considerations. A comprehensive literature search was conducted, and eight relevant studies were included. The methodological quality of the studies was assessed, and findings were synthesized narratively due to variability in study designs. Overall, MRI showed a higher detection rate for underlying causes of dizziness compared to CT, particularly for posterior circulation strokes. CT was mainly useful for ruling out hemorrhage, while MRI offered superior detection of ischemic events. Using clinical factors such as age, vascular risk, and neurological findings may help prioritize MRI use in patients with higher stroke risk, supporting targeted imaging strategies to improve diagnostic outcomes and resource utilization.

DOI: 10.7759/cureus.88057

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Association Between Stone Composition and Recurrence Rates Following Ureteroscopy: A Scoping Review (2025)

Type of publication:

Journal article

Author(s):

George, Althea O; Adefehinti, Mayowa; Lee, Minwook; Adebisi, Ajibola A; *Odedara, Ayodele; Omiko, Raymond; Akinwale, Mobolaji; Ndonga, Steven; Olalekan, Adeyeye; Yusuf, Abdulhameed; Ali, Sahar; Ononye, Reginald; Onobun, Daniel E.

Citation:

Cureus. 17(7):e87602, 2025 Jul.

Abstract:

Urolithiasis remains a significant global health burden, with high recurrence rates following intervention. Ureteroscopy is increasingly preferred due to its safety and efficacy; however, recurrence after ureteroscopy is common and may be influenced by stone composition. This scoping review aims to explore the relationship between stone composition and recurrence rates post-ureteroscopy and to identify gaps in current evidence that could inform clinical practice and research. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines, we conducted a structured literature search (2014-2024) across PubMed, Scopus, MEDLINE, and Google Scholar. Studies were eligible if they reported on adult patients (>=18 years) undergoing ureteroscopy for renal or ureteric stones, provided stone composition data, and reported recurrence (defined radiologically, symptomatically, or via reintervention). Retrospective/prospective cohort studies, clinical trials, and case series (n >10) in English were included. Non-English, paediatric-only studies, case reports, and those lacking recurrence or composition data were excluded. In total, 13 studies met the inclusion criteria. Calcium oxalate was the most frequently reported stone type and appeared to be associated with higher recurrence rates. Reported recurrence ranged from 25.8% at 32 months to nearly 60% at 36 months, particularly in patients without metabolic follow-up. Reporting of uric acid, struvite, and cystine stones was inconsistent, limiting firm conclusions. The majority of studies were retrospective, small-scale, and lacked standardised definitions of recurrence, often conflating residual fragments with true recurrence. Language restriction and lack of granular metabolic data further limited synthesis. Stone composition appears to influence recurrence risk post-ureteroscopy, particularly for calcium-based stones. However, variability in study design, recurrence definitions, and underreporting of metabolic data reduce the strength of current evidence. Future prospective research with standardised reporting and broader linguistic inclusion is essential.

DOI: 10.7759/cureus.87602

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Implementing Quick Response (QR)-Coded Patient Information Leaflets to Reduce Environmental Impact in Urology Outpatient Clinics: A Pilot Study (2025)

Type of publication:

Journal article

Author(s):

Matei, Ana; *Chin, Yew Fung; Hughes, Thomas; Mahmalji, Wasim.

Citation:

Cureus. 17(7):e87891, 2025 Jul.

Abstract:

Background and aim Patient information leaflets (PILs) printed in paper form are a commonly used adjunct tool in urology clinics. These help to facilitate the information transfer between doctor and patient. They are detrimental to the environment and costly. Quick response (QR) codes can be used as another option for delivering the leaflets and would reduce the environmental burden. The aim of this paper is to evaluate patient response to the introduction of QR codes as a replacement for paper-based PILs. Methods This pilot study followed the introduction of QR codes of commonly used leaflets sourced from the British Association of Urological Surgeons (BAUS). The study was conducted in a urology clinic at the Hereford County Hospital over a one-month period. The acceptability of the QR codes was recorded. Data such as patient demographics and the type of leaflet were also documented and tabulated. Results Thirty-one patients required PILs, out of which 80% agreed to PILs via QR codes. The mean age of the participating patients was 76. The replacement of paper with QR codes for the one-month period reflects an average estimated saving of 1.88 kg of carbon dioxide emissions and around 238 sheets of paper. Discussion The introduction of QR codes has seen an increase in most sectors, including, more recently, the medical industry. They can be used with a wide range of functions within the industry ranging from medical education to patient identification. These can also be more easily distributed in various forms to cater to all needs. Limitations, such as the currently limited variety of urology PILs available, also need to be considered. Conclusion QR codes of the PILs are a generally accepted alternative. The widespread introduction of QR codes reduces the total environmental impact of paper documents while also reducing production costs.

DOI: 10.7759/cureus.87891

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Safety of pembrolizumab in advanced head and neck squamous cell carcinoma: A systematic review and meta-analysis of RCTs (2025)

Type of publication:

Conference abstract

Author(s):

Ahad A.; Kumar S.; Kolomar H.; Wang J.; Mylavarapu M.; *Yateem D.; Sadeghzadegan A.; Abdallah A.; Chowdhury D.; Alnajar F.; Hassan M.J.; Kharel P.; Ali M.;

Citation:

Journal of Clinical Oncology. Conference: 2025 ASCO Annual Meeting I. Chicago, IL United States. 43(16 Supplement) (no pagination), 2025. Date of Publication: 01 Jun 2025.

Abstract:

Background: Pembrolizumab, a checkpoint inhibitor, has demonstrated safety and efficacy in various cancers, primarily melanomas and non-small cell lung cancers. However, its safety profile in Head and Neck Squamous Cell Carcinoma (HNSCC) remains inadequately studied. This meta-analysis aims to evaluate adverse events (AEs) associated with pembrolizumab in patients with advanced HNSCC. Method(s): A systematic search was conducted using PubMed, Embase, Cochrane Library, Web of Science, and clinicaltrials.gov. Randomized controlled trials (RCTs) evaluating pembrolizumab monotherapy in patients with advanced HNSCC were included. Primary outcomes included overall AEs, grade 3-5 AEs, immune-related AEs, and treatment discontinuation due to AEs. Random effects models were used for analysis. Statistical analysis was performed using Review Manager 5.4 (RevMan). A p-value <= 0.05 was considered statistically significant. Result(s): A total of 1,900 patients (mean age: 59.86 +/- 9.1 years; females: 16.73%) with advanced HNSCC were included from three RCTs. Patients receiving pembrolizumab monotherapy had higher odds of experiencing overall AEs (OR 2.00, 95% CI 1.04-3.83, p = 0.04), grade 3-5 AEs (OR 1.13, 95% CI 0.68-1.86, p = 0.63), immune-related AEs (OR 1.49, 95% CI 0.44-5.08, p = 0.53), and lower odds of treatment discontinuation due to AEs (OR 0.77, 95% CI 0.34-1.75, p = 0.53) compared to the control group. However, only overall AEs were statistically significant. Conclusion(s): Pembrolizumab is associated with a higher risk of AEs in patients with advanced HNSCC compared to the control group. Interestingly, the likelihood of treatment discontinuation due to AEs was lower in the pembrolizumab group; however, this difference was not statistically significant. Further research, including larger RCTs with longer follow-up periods, is necessary to evaluate the safety profile of pembrolizumab in patients comprehensively. Additionally, studies should focus on identifying specific patient subgroups at greater risk for AEs and exploring strategies to mitigate these risks.

Developing a Triage Rag Tool to Standardise the Triage of Referrals Received by the Palliative Care Team in the Hospital Setting (2025)

Type of publication:

Conference abstract

Author(s):

*Shellis K.; *Corbett E.; *West D.;

Citation:

BMJ Supportive and Palliative Care. Conference: Palliative Care Congress. Belfast Ireland. 15(Supplement 2) (pp A56), 2025. Date of Publication: 01 Mar 2025.

Abstract:

Background During 2022 we realised that we needed to standardise our approach to managing the referrals received to the specialist palliative care team in the acute hospital trust. This was something that had been highlighted in our previous CQC inspection and we understood the importance of assessing patients according to their acuity in a timely manner. Prior to the development of this tool there was no standardised way of triaging patients and often there would be variation in the responsiveness of the service. Aim of the triage RAG The purpose of this tool was to ensure we offered an equitable service to our patients across both of our hospital sites ensuring that those with the highest acuity had an urgent response time of 4 hours (red), those with moderate symptoms/concerns were seen in within 24 hours and those with low acuity were seen within 48 hours. Method The palliative care team worked together through our team meetings to review current literature and best practice. We devised the tool based on most common symptom presentations and most prevalent reasons for referral. We initially trialled this alongside our electronic referral form but we found that we also need a series of question prompts and therefore, this was added to our tool. The tool was trialled for an initial period of six months and following this the final version was presented at out Palliative and End of Life Steering group and subsequently adopted by the whole team. Results We are now able to monitor and report our triage times via our dashboard, we have a standardised way of prioriting our caseload and ensuring the right patients get the correct response from the acute specialist palliative care team, therefore improving patient outcomes.

DOI: 10.1136/spcare-2025-PCC.144

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The 3,550 g Challenge: An Atypical Presentation of a 3.5 kg Seminoma Manifesting as Dry Skin (2025)

Type of publication:

Journal article

Author(s):

Omorphos, Nicolas; Mohsin, Mohamed Shamil; *Mok, Spencer; Kitchen, Mark; Ho, Kuo J.

Citation:

Cureus. 17(7):e87174, 2025 Jul.

Abstract:

A 43-year-old male presented to the emergency department with a seven-year history of progressive left-sided scrotal swelling. On examination, a large mass was palpable in the left hemiscrotum, accompanied by eczema-like skin changes and a decubitus ulcer. Tumor markers were significantly elevated, particularly lactate dehydrogenase, and an urgent ultrasound confirmed the presence of a testicular tumor. CT revealed a scrotal mass originating from the left testis, along with bilateral inguinal lymphadenopathy. The patient underwent a left inguinal orchidectomy, and histopathological analysis confirmed a 3,550 g classical seminoma. He was subsequently referred to oncology for adjuvant chemotherapy.

DOI: 10.7759/cureus.87174

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Barriers to the safe discussion of the experience and management of menopausal symptoms: A systematic literature review (2025)

Type of publication:

Journal article

Author(s):

Thavabalan, Karish; *Ovenell, Alistair; Pierce, Poppy; Sutaria, Aman; Parkhouse, Annabelle; Baydemir, Numan; Lally, Theodore.

Citation:

Maturitas. 201:108683, 2025 Aug 05.

Abstract:

As the number of women experiencing menopause continues to rise each year, the need for open and supportive discussions around the experience and management of menopausal symptoms becomes more imperative. Although research has identified numerous challenges women face during this life stage, many studies examine these barriers in isolated settings. Furthermore, how these challenges impact women's ability to safely discuss menopause remains poorly understood. This systematic literature review
sought to identify and synthesise the barriers that hinder safe discussions about the experience and management of menopausal symptoms. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, 21 qualitative studies were included. Six themes were identified regarding symptom experience: lack of support from friends and family, lack of workplace support, fear of menopause onset, variation in symptom experience, poor-quality information, and societal judgement. Two themes were identified regarding symptom management: perceived onus to endure symptoms and poor experiences with healthcare professionals. Notably, the themes revealed widespread shortcomings that collectively hinder safe discussions about menopause. Future work should prioritise intersectional approaches that tackle barriers across home, social, work, and healthcare settings. Proactive measures, such as placing a greater emphasis on menopause in medical education and developing culturally relevant resources, are crucial for fostering safe, informed discussions and improving care for all women.

DOI: 10.1016/j.maturitas.2025.108683

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Colorectal Cancer Mortality Rates in UK Shropshire County (2025)

Type of publication:

Conference abstract

Author(s):

*Shah J.; *Shittu S.; *Goh Y.L.; *Ball W.;

Citation:

British Journal of Surgery. Conference: 49th ASiT Annual Surgical Conference. Belfast United Kingdom. 112(Supplement 10) (pp x64), 2025. Date of Publication: 01 Jun 2025.

Abstract:

Aim: Evaluate outcomes of patients dying within 12 months from diagnosis of colorectal cancer in Shropshire County. Method(s): Single-centre retrospective review of patients who died within 12 months of diagnosis between 2020-2024.Each patient's hospital records were reviewed, and data were collected on patient demographics, performance status, time from referral to imaging, diagnosis, MDT, death and treatment intent. Result(s): A total of 103(44 male: 59 female) patients,with a mean age at referral of 74 (range 32 – 96) years old. Most patients had a performance status of 1 and lived in their own home (92%). 60% of patients lived in Shrewsbury, 34% in Telford and 9% in Wolverhampton. Referral sources were mainly from GP (55%), emergency admission to SAU (20%) and AMU (16%).74% of GP referrals were seen within two weeks. All patients underwent CT imaging. Endoscopic procedures were performed in 57% of patients. The average age of death is 75 (range 34 – 97) years old, most commonly from distant metastatic sigmoid cancer. The average time between diagnosis and death was 4.4 months.Treatment intent was palliative in 90% (BSC in 44% and oncology in 56%).59% who were referred to oncology received palliative treatment. Eight patients were treated with curative intent but died due to sepsis and multiorgan failure(2), died prior to commencing treatment (1), complications from treatment (3) or declined treatment (2). Conclusion(s): This snapshot audit demonstrates that patients in Shropshire County newly diagnosed with colorectal cancer were elderly, aged over 70 years old with significant cardiovascular co-morbidities and performance status of at least 1.

DOI: 10.1093/bjs/znaf128.248

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