Artificial Intelligence and Digital Therapy for Adolescent Mental Health in the UK; Opportunities, Barriers, and Ethical Consideration (2025)

Type of publication:

Journal article

Author(s):

Adindu K.N.; Akubue N.; Jude N.O.; Onakoya A.; Chukwunonye C.; Odion O.; *Okengwu C.G.; Uchechukwu N.; Osita-Obasi P.Z.; Ezike A.; Bello I.; Olenloa E.; Eruteya O.O.; Oyewole S.A.

Citation:

SSRN. (no pagination), 2025. Date of Publication: 20 May 2025.

Abstract:

Background: Adolescence constitutes a critical developmental stage marked by the onset of mental health difficulties, yet timely access to effective mental health care remains a significant challenge for many adolescents in the United Kingdom (UK). Artificial intelligence (AI)-enabled digital therapies present innovative opportunities to address these gaps. Objective(s): This systematic review critically assesses current evidence on AI-driven digital interventions for adolescent mental health within the UK, highlighting their potential opportunities, barriers to implementation, and pertinent ethical considerations. Method(s): Employing a mixed-methods design, a systematic literature review adhering to PRISMA guidelines was combined with thematic analysis of semi-structured interviews. Comprehensive database searches (MEDLINE, PsycINFO, Web of Science; 2013-2023) targeted studies involving UK adolescents (ages 11-19) using AI-based mental health technologies. Included studies underwent rigorous quality appraisal (Cochrane RoB 2.0, ROBINS-I, CASP). Additional insights were gathered through stakeholder interviews (clinicians, AI developers, adolescent users). Result(s): Twenty-seven studies met inclusion criteria, investigating interventions such as AI chatbots, predictive analytics, mobile apps, and virtual environments targeting anxiety and depression. Key opportunities identified include enhanced accessibility for underserved populations, personalization through adaptive algorithms, proactive early-risk detection, scalability, cost-efficiency, and improved engagement via interactive interfaces. Significant implementation barriers encompassed technical infrastructure limitations, data security concerns, insufficient longitudinal efficacy data, socioeconomic disparities, and clinician scepticism. Ethical challenges emphasized informed consent, algorithm transparency, potential biases, unclear accountability, and clinician deskilling risks. Conclusion(s): AI-driven digital interventions offer substantial promise for augmenting adolescent mental health services in the UK. However, realizing their full potential necessitates addressing infrastructural, ethical, and evidentiary challenges through robust governance frameworks and continued rigorous research.

DOI: 10.2139/ssrn.5253224

Link to full-text [open access - no password required]

The Role of Neuroinflammation in Chronic Dermatological Disorders: A Psychodermatological Perspective (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 95), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: Chronic dermatological conditions such as psoriasis, atopic dermatitis, and hidradenitis suppurativa exhibit a complex interplay between neuroinflammation and psychological distress. The bidirectional relationship between cutaneous inflammation and psychiatric morbidity suggests that systemic inflammatory mediators play a pivotal role in exacerbating both dermatological and psychiatric symptoms. This abstract explores existing literature on neuroinflammation in psychodermatology, highlighting its impact on disease progression and mental health comorbidities. Material(s) and Method(s): A comprehensive review of peer-reviewed literature from PubMed, Scopus, and Embase was conducted to assess the role of neuroinflammatory pathways in dermatological conditions. Studies analyzing inflammatory biomarkers, neuroimmune interactions, and psychodermatological interventions were included. The review focused on the correlation between inflammatory markers and psychiatric distress in patients with chronic skin disorders. Result(s): Existing studies indicate a significant association between elevated inflammatory markers (interleukin-6, tumor necrosis factor-alpha, C-reactive protein) and increased psychiatric distress in chronic skin conditions. Psychological interventions such as cognitive-behavioral therapy and stress-reduction techniques demonstrate potential in modulating inflammation and improving patient-reported outcomes. Emerging therapeutic approaches targeting the neuroimmune axis, including biologic agents and psychoneuroimmunological interventions, are also discussed. Conclusion(s): This review highlights the integral role of neuroinflammation in psychodermatology and underscores the need for a multidisciplinary approach to managing chronic dermatological disorders. Future research should explore targeted neuroimmune therapies and integrative mental health interventions to optimize patient care and quality of life in psychodermatology.

Hidradenitis Suppurativa: Addressing the Hidden Psychological Burden Beyond Skin Lesions (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 94), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with profound psychological consequences. Patients experience significant social stigma, depression, and reduced quality of life due to recurrent painful lesions and scarring. This abstract reviews the current literature on the psychological burden of HS and the importance of incorporating mental health care in disease management. Material(s) and Method(s): A review of published studies from PubMed and Embase was conducted to assess the psychological impact of HS. Research on depression, anxiety, social withdrawal, and dermatology life quality index scores in HS patients was analyzed. The review also explored potential benefits of psychodermatological interventions. Result(s): Studies highlight that 40%-50% of HS patients experience moderate-to-severe depression, with a high incidence of anxiety and social isolation. HS is associated with an increased risk of suicidal ideation compared to other dermatological conditions. Multidisciplinary management incorporating dermatologists, psychologists, and pain specialists has shown promise in improving patient outcomes. Conclusion(s): The psychological burden of HS is often overlooked in standard dermatological care. Early screening for mental health conditions and the inclusion of psychotherapeutic support should be prioritized in HS management. Future research should focus on the efficacy of integrated psychodermatology approaches to improve quality of life in HS patients.

Digital Media, Acne Dysmorphia and Social Anxiety: The Emerging "Filter Dysmorphia" Epidemic (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 153), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: The increasing prevalence of social media has contributed to heightened appearance-related anxiety and unrealistic beauty standards, leading to a phenomenon known as "filter dysmorphia". This abstract explores existing literature on the impact of digital media on acne dysmorphia, social anxiety, and dermatological self-perception. Material(s) and Method(s): A literature review was conducted on studies examining the psychological impact of social media exposure on skin-related concerns. Research on acne dysmorphia, social anxiety disorder, and the influence of digital filters on self-image was analyzed. Result(s): Evidence suggests that excessive social media engagement correlates with increased acne-related anxiety, negative self-perception, and a higher likelihood of seeking unnecessary dermatological interventions. Filter dysmorphia appears to contribute to an increase in perceived acne severity, despite objective clinical findings remaining unchanged. Conclusion(s): Dermatologists should be aware of the psychological influence of digital media on patient self-perception and incorporate screening tools for acne dysmorphia and social anxiety in clinical practice. Future research should explore the role of media literacy programs and psychological interventions in mitigating the negative impact of digital media on dermatological concerns.

The Role of Psych Dermatology in Patients Undergoing Treatment for Autoimmune Bullous Dermatoses: A Neglected Domain (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 96), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: Autoimmune bullous dermatoses (ABD), including pemphigus vulgaris and bullous pemphigoid, are associated with significant physical and psychological distress. The chronic nature of these conditions, coupled with the adverse effects of long-term immunosuppressive treatment, places a considerable burden on mental health. This abstract reviews the role of psychodermatology in the holistic management of ABD patients and the need for integrated psychological support. Material(s) and Method(s): A literature review was conducted using PubMed and Scopus databases to analyze studies evaluating the psychological impact of ABD. Research on anxiety, depression, and quality-of-life measures in patients undergoing long-term immunosuppressive therapy was included. The review also assessed interventions such as psychotropic medications, cognitive-behavioral therapy, and patient support groups. Result(s): Findings indicate a high prevalence of psychiatric comorbidities among ABD patients, including depression (35%-50%) and anxiety (30%-45%). Psychological distress contributes to reduced treatment adherence and worsened disease prognosis. Evidence suggests that integrating psychodermatological care, including psychotherapy and psychiatric evaluation, improves patient-reported outcomes and treatment compliance. Conclusion(s): Despite the significant psychological burden in ABD patients, psychodermatology remains underutilized in their management. Future research should explore standardized screening for psychiatric distress in ABD and assess the long-term benefits of psychodermatological interventions. Dermatologists should consider integrating mental health support into routine care to enhance patient well-being.

Trichotillomania and Psychogenic Hair Loss: A Review of Integrated Treatment Strategies (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 96), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: Trichotillomania (TTM) and stress-related hair loss significantly impact quality of life and are often resistant to conventional dermatological treatments. Understanding the psychological mechanisms underlying compulsive hair-pulling and stress-induced alopecia is essential for improving patient outcomes. This abstract presents a review of literature on integrated treatment approaches for TTM and psychogenic alopecia. Materials and Methods: A literature review of PubMed and Cochrane databases was conducted, focusing on treatment modalities combining dermatological and psychological interventions. Studies assessing cognitive-behavioral therapy (CBT), mindfulness-based therapies, and pharmacological interventions for TTM were included. The review also examined adjunctive dermatological therapies such as low-level laser therapy and platelet-rich plasma. Result(s): Studies indicate that CBT and habit-reversal training are among the most effective psychological treatments for TTM. Emerging evidence suggests that mindfulness techniques and pharmacological agents, such as selective serotonin reuptake inhibitors, can complement dermatological therapies. Integrated management strategies, incorporating both psychiatric and dermatological interventions, show superior outcomes compared to monotherapy. Conclusion(s): Multimodal treatment approaches addressing both the psychological and dermatological aspects of TTM and psychogenic hair loss yield better patient outcomes. Dermatologists should consider collaborative care models incorporating psychiatric support to optimize treatment efficacy. Further research into novel therapeutic interventions is warranted.

Cosmetic Dermatology and Body Dysmorphic Disorder: A Clinical Review of Screening and Management Strategies (2025)

Type of publication:

Conference abstract

Author(s):

*Mehra S.

Citation:

Turkish Journal of Dermatology. Conference: 21st Congress of the European Society for Dermatology and Psychiatry and 1st World Congress of Psychodermatology. Istanbul Turkey. 19(1 Supplement 1) (pp 142), 2025. Date of Publication: 01 May 2025.

Abstract:

Aim: Body dysmorphic disorder (BDD) is a psychiatric condition with a significant impact on cosmetic dermatology. The increasing accessibility of aesthetic procedures has led to concerns regarding undiagnosed BDD in patients seeking cosmetic enhancements. This abstract explores the literature on the prevalence, screening methods, and management strategies for BDD in cosmetic dermatology settings. Material(s) and Method(s): A systematic review of literature from PubMed and Embase was conducted to evaluate validated screening tools for BDD in dermatological practice. Studies examining the psychological impact of aesthetic interventions on BDD patients were analyzed. The review also assessed proposed multidisciplinary management strategies incorporating psychiatry and dermatology. Result(s): Findings suggest that BDD is underdiagnosed in dermatology settings, with prevalence rates ranging between 9-15% in cosmetic patients. Psychological distress often worsens post-intervention in untreated BDD cases. Screening tools such as the BDD Questionnaire and structured psychiatric assessments can improve early detection. Multidisciplinary collaboration between dermatologists and mental health professionals is essential for optimizing patient outcomes and preventing unnecessary procedures. Conclusion(s): Recognizing BDD in cosmetic dermatology is crucial to avoid worsening psychological distress in vulnerable patients. Implementing routine screening and referral pathways for psychiatric assessment can improve patient care. Future research should focus on standardized screening protocols and therapeutic interventions tailored to dermatology patients with suspected BDD.

Is Follow Up for Lung Cancer Surgery Evidence Based Within the UK - a Critical Review of Protocols (2025)

Type of publication:

Conference abstract

Author(s):

Barton P.W.J.; *McAdam J.; James T.; Gomez S.; Morley J.; Dalrymple P.; Smith C.; Ivey S.

Citation:

Journal of Thoracic Oncology. Conference: 2025 World Conference on Lung Cancer. Barcelona Spain. 20(10 Supplement 1) (pp S873), 2025. Date of Publication: 01 Oct 2025.

Abstract:

Introduction: Our aim is to look at surgical follow-up protocols in different UK trusts to critically review and see if follow up varies postsurgical patient with lung cancer. Method(s): A literature review around this topic was conducted to establish if there was an evidence based approach. We collected follow up protocols from 10 trusts in the UK and applied 6 questions to each to allow us to compare the results. Responses were collated, compared and interpreted by the authors. Result(s): Our literature review highlighted there is limited evidence to support how lung cancer patients should be followed up post-surgery. Overall, the literature supports CT based imaging although no specific period is supported. From the protocols reviewed there were common themes identified. Post-surgical follow-up was predominantly nurse led, face to face appointments or mixed with virtual were more common. Frequency of follow-up varied between 3 and 8 months, but apart from one site was consistently over 5 years. Similarly, radiology modality predominantly used CT scan either solely or mixed with chest x-rays. Only one site only used chest x-rays to follow up patients Conclusion(s): Both the literature review and critical review of protocols highlight that further research would be beneficial, looking at a wider population of protocols could help encourage a more standardised approach across the UK to ensure optimum care for patients.

DOI: 10.1016/j.jtho.2025.09.1695

Patient's Understanding of Follow-Up Post Curative Primary Lung Cancer Surgery (2025)

Type of publication:

Conference abstract

Author(s):

Barton P.W.J.; King M.; *Wassell E.; *McAdam J.

Citation:

Journal of Thoracic Oncology. Conference: 2025 World Conference on Lung Cancer. Barcelona Spain. 20(10 Supplement 1) (pp S872), 2025. Date of Publication: 01 Oct 2025.

Abstract:

Introduction: Follow up is an important part of patient care post primary lung cancer resection due to the possibility of cancer recurrence or the development of a new primary lung cancer. We aim to explore post operative patient's with a lung cancer understanding of follow-up and how we can implement and support this practice. Method(s): Between 01/08/2023 and 31/08/2023 every curative intent surgical patient was given a questionnaire to complete whilst attending follow-up clinics. This was rolled out over three UK thoracic surgical centers/Diagnostic centers and targeted patients with lung cancer undergoing follow-up post curative primary lung cancer surgery (excluding carcinoids, recurrence). 148/155 questionnaires were returned, collecting information on demographics, smoking status, operation performed, follow-up period post-surgery and patient understanding of follow-up. The responses were collated, compared and interpreted by the authors. Result(s): 148/155 (96%) patients responded. 62% female, 36% male. 80% Ex-smokers, Lobectomy most common operation 64%. 97% of patients' aware follow-up was required, and 72% identified that this would be for 5 years. 68% knew their diagnosis prior to surgery and 58% their final staging, 9% understood TNM. 58% knew their lung cancer nurse specialist (LCNS) and 54% when radiological investigations would be performed. 57% recall being given advice on improving their health and wellbeing, from (LCNS) 30%. 45% recalled a healthcare professional discussing recurrence. 34% knew the potential signs and symptoms of recurrence. Conclusion(s): This study has identified a gap in patients' knowledge and understanding of follow-up: The necessity of followup; TNM stage relevant to individuals; Schedule and frequency of radiological tests; Signs and symptoms suggestive of lung cancer recurrence. The development of a information leaflet patients with lung cancer by LCNS aims to address this need.

DOI: 10.1016/j.jtho.2025.09.1691